All About Vitamins: Niacin in Inhibited Inflammatory Expression

By Kyle J. Norton.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Inflammation is a natural response of immune system in protection of our body against foreign invasion and prevent further damage to injured or damage body's tissues and organs. Over expression of immunity in this case may cause complications if not under controlled.

Niacin is found to inhibit inflammatory expression through its anti-nociceptive activity, a renowned institutes joint study suggested.

According to the Universidade de São Paulo, nicotinic acid (Hnic) and its isomer isonicotinic acid (ina) activated ligands (L) from niacin displayed anti inflammatory effect in inhibition of mechanical hyperalgesia induced by prostaglandin E2, carrageenan, a common food additive and antigen-induced arthritis.

Furthermore, in animal study, mice induced inflammation by formalin.fed with nicotinic acid (250, 500 or 1000 mg/kg, -1 h) showed a significant effect in demonstrated anti the first and the second phases of the nociceptive response against pain expression.
At dose (250 or 500 mg/kg, -1 and 3 h) nicotinic acid also displayed a decreased mechanical allodynia in triggering pain response from stimuli which provoke pain induced by carrageenan, in rat model.

Additionally, besides reduced inflammatory activity against pain, nicotinic acid (250 or 500 mg/kg, p.o., -1 and 3 h) also expressed an ameliorated paw edema caused by carrageenan.

Dr. Godin AM, the lead author said, " our results represent the first demonstration of the activity of nicotinic acid in experimental models of nociceptive and inflammatory pain and also provide further support to its anti-inflammatory activity. It is unlikely that conversion to nicotinamide represents an important mechanism to explain the antinociceptive and anti-inflammatory activities of nicotinic acid".

Taking together, nicotinic acid, a drug that has already been approved for clinical use with a positive safety record to treat high cholesterol and heart disease , may be used as anti inflammatory agent in reduced complications caused over reaction of immunity.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Anti-inflammatory and Anti-nociceptive Activity of Ruthenium Complexes with Isonicotinic and Nicotinic Acids (Niacin) as Ligands by Freitas CS1, Roveda AC Jr2, Truzzi DR2, Garcia AC2, Cunha TM1, Cunha FQ1, Franco DW2.(PubMed)
(2) Nicotinic acid induces antinociceptive and anti-inflammatory effects in different experimental models by Godin AM1, Ferreira WC, Rocha LT, Ferreira RG, Paiva AL, Merlo LA, Nascimento EB Jr, Bastos LF, Coelho MM.(PubMed)