All About Vitamins: Niacin in Reduced risk Skin Cancer

By Kyle J. Norton.


Nicotinamide, an amide form of vitamin B3, may have a potential effect in reduced risk of skin cancer of type squamous cell carcinoma (SCC), the recent respectable university suggested.

Niacin, is also known as vitamin B3, nicotinic acid, an organic compound with the formula
C6H5NO2, found abundantly in chicken, beef, fish, cereal, peanuts and legumes. It is best known for its effects in lowering cholesterol and triglycerides and removing toxic from our body and promoting production of steroid hormones.

Skin cancer is a condition characterized by abnormal cell group in skin of the body.

In the review of 72,308 women in the Nurses' Health Study (1984-2010) and 41,808 men in the Health Professionals Follow-up Study (1986-2010), with niacin intake assessed every 2 to 4 years during follow-up and cumulative averaged intake,  niacin injection was inversely associated with risk of skin cancer in total documented 23,256 BCC, 2,530 SCC and 887 melanoma cases.

The investigation also addressed the gender different in higher total niacin intake and risk of melanoma.  As men is found to marginally positively associated with melanoma risk, but not in women.

Also, according to the study, niacin may be effective in reduced risk and treatment of skin cancer of type squamous cell carcinoma (SCC) but not of BCC or melanoma.

Other researchers in the human trials of phase 3, double-blind, randomized, controlled trial, randomly assigned, in a 1:1 ratio of 386 participants who had had at least two nonmelanoma skin cancers in the previous 5 years to receive 500 mg of nicotinamide twice daily or placebo for 12 months witj participants evaluated by dermatologists at 3-month intervals for 18 months, suggested that treated patient showed a significant lowering nonmelanoma skin cancers by 23% at 12 months with compared placebo.

Both groups expressed  the similar differences with respect to new cases of basal-cell carcinomas and new squamous-cell carcinomas.

Also in compared to placebo, nicotinamide group showed a lower of number of actinic keratoses incidence, a scaly growth caused by damage from exposure to ultraviolet (UV) radiation  by 11% at 3 months (P=0.01), 14% lower at 6 months (P<0.001), 20% lower at 9 months (P<0.001), and 13% lower at 12 months (P=0.001).

Taking together, Niacin and it's dietaryNicotinamide may be a potential and therapeutic vitamin supplements for reduced risk and treatment for certain types of skin cancer.

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Nicotinamide and the skin by Chen AC1, Damian DL.(PubMed)
(2) Niacin intake and risk of skin cancer in US women and men by Park SM1,2,3, Li T1, Wu S4,5, Li WQ4,6, Weinstock M4,6,7,8, Qureshi AA1,4,6,8, Cho E1,4,6.(PubMed)
(3) A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention by Chen AC1, Martin AJ, Choy B, Fernández-Peñas P, Dalziell RA, McKenzie CA, Scolyer RA, Dhillon HM, Vardy JL, Kricker A, St George G, Chinniah N, Halliday GM, Damian DL.(PubMed)