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Monday, October 16, 2017

All About Vitamins: Vitamin B5(Pantothenic acid) in Reduced Risk Of Non Alcoholic Liver Disease?

By Kyle J. Norton

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5

Vitamin B5 deficiency may have a significant effect in Risk Of Non Alcoholic Liver Disease, a respectable institute study suggested.

In the evaluated methionine-choline deficient (MCD) and Western diet mouse models of NASH, with MCD diet-fed mice treated with pantothenate and N-acetylcysteine or placebo, researcher at the joint study lead by the Duke University Medical Center, suggested that treatment with pantothenate and N-acetylcysteine did not inhibit caspase-2 activation, improve NASH, normalize PANK expression, or restore free CoA levels in MCD diet-fed mice evn though antothenic acid (PaA) is a vitamin fromed an integral part of coenzyme A (CoA).

The result indicated that Pantothenic acid have a insignificant effect in reduced risk and treatment of Nonalcoholic fatty liver disease (NAFLD).

Contrast to the above differentiation, the university of Shiga Prefecture study of PaA deficiency in increased risk of accumulation of tissue fats, with Weaning rats fed the PaA-free diet for 30 d. Rats, then divided into two groups. One group was continuously fed the PaA-free diet, and the other was fed the PaA-containing diet for an additional 13 d, reported the following results
1. Fat accumulated by consuming the PaA-free diet for 30 d was decreased by consuming the PaA-containing diet for an additional 13 d.
2. PaA-free diet feeding elicited much greater accumulation of liver, perinephric, and plasma fats.
3.. Administration of PaA expressed a strong effect in decreased accumulated fat.

Dr. Shibata K, the lead author said, "PaA deficiency causes fat accumulation, and re administration of PaA decreases the tissue fat in rats fed the pantothenic acid-free diet".

Furthermore, in the evaluated mice lacking mitochondrial 3-hydroxymethylglutaryl CoA synthase (HMGCS2) to determine the role of ketogenesis in preventing diet-induced steatohepatitis, researchers showd that intake of supplementation of the CoASH precursors pantothenic acid and cysteine normalized TCA intermediates and gluconeogenesis in the liver, resulting in ameliorately hepatocyte injury and inflammation, decreased glycemia,.......

In regard to the information collected, further cohost and large sample size studies are necessary to confirm either ways.


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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model by Machado MV1,2, Kruger L1, Jewell ML1, Michelotti GA1, Pereira Tde A1, Xie G1, Moylan CA1, Diehl AM3.(PubMed)
(2) Pantothenic acid refeeding diminishes the liver, perinephrical fats, and plasma fats accumulated by pantothenic acid deficiency and/or ethanol consumption by Shibata K1, Fukuwatari T, Higashiyama S, Sugita C, Azumano I, Onda M.(PubMed)
(3) Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia by Cotter DG, Ercal B, Huang X, Leid JM, d'Avignon DA, Graham MJ, Dietzen DJ, Brunt EM, Patti GJ, Crawford PA.(PubMed)

Friday, October 13, 2017

All About Vitamins: Vitamin B5(Pantothenic acid) Deficiency in Risk Of Osteoarthritis

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Pantothenic acid deficiency may be associated to risk of osteoarthritis, a study by renowned institute suggested.

In the study of 77 osteoarthritis patients assessed biweekly for 12 weeks as part of a multidisciplinary approach to the management of osteoarthritis, nutrient information and food frequency questionnaire returned by patients, showed a significantly correlated between obesity pain from osteoarthritis and vitamins deficiency, particularly vitamin B5.

According to the study, obese osteoarthritis patients may benefit from weight loss if meal were chosen with care to include nutrients in which they are deficient.

Dr. White-O'Connor B, the lead author said, " In addition to providing nutritional recommendations to avoid dietary deficiencies, a registered dietitian can assist in the multidisciplinary treatment of osteoarthritis by providing weight-control counseling and follow-up".

In deed, further differentiation showed that  dietary intake of these group of patients were below 80% of pantothenic acid, the recommended dietary allowance daily. 

Other, in the study of vitamin therapy in the absence of obvious deficiency opinionated that deficiency of vitamin may lead to a specific deficiency syndrome, which may be primary (due to inadequate diet) or secondary (due to malabsorption or to increased metabolic need), and it is rational to use high-dose vitamin supplementation in situations where these clinical conditions exist and vitamin B5 deficiency is associated to increased risk and progression of osteoarthritis.

Dr. Ovesen L. said, "Most of the vitamins have been reported to cause adverse effects when ingested in excessive doses" and "therefore worthwhile to consider the risk-benefit ratio before embarking upon the use of high-dose vitamin supplementation for disorders were proof of efficacy is lacking".

Taking altogether, vitamin B5 deficiency may be one of major factor in increased incidence and progression of osteoarthritis, therefore intake of supplement may be necessary but please consult with your doctor before applying in large doses.


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FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Sources


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Nutrient intake and obesity in a multidisciplinary assessment of osteoarthritis by White-O'Connor B, Sobal J.(PubMed)

Thursday, October 12, 2017

All About Vitamins: Vitamin B5(Pantothenic acid) Deficiency in Risk Of Hypertension

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Vitamin B5 deficiency may have a profound and positive effect in promoted hypertension, an Asian study postulated.

In the study of endemic pantothenic acid deficiency of some Japanese populations and risk of increased occurrence of hypertension suggested that pantothenic acid deficiency is a factor in the experimental origin of hypertension due to adrenal regeneration, but in most cases, blood samples observations of vitamin B5 expression have largely been ignored.

Dr. Schwabedal PE, ignorance of vitamin B5 deficiency may put many patient of these group at risk of cardiovascular disease due to undiscovered of high blood pressure, one of risk factors of CVD incidence.

Other, in the examined 171 patients with hypertension and coronary heart disease, researchers found that there are association between vitamin decreased as the disease progressed and heart failure supervened.

More interestingly, in the study of Vitamin D and B100 oral administration to 1000 neurology patients with sleep characteristics, pain levels, neurologic symptoms, and bowel complaints were recorded by the author at routine appointments, researchers indicated that oral administrated group showed to improve sleep and more cellular repairs eventually depletes body stores of pantothenic acid, causing reduced cortisol production, and increased sympathetic tone in produced hypertension  and a "hyper-adrenergic" state known to predispose to heart disease and stroke.

Taking together, vitamin B5 deficiency may have a profound effect in increased risk of hypertension, a major risk factor of CVD development.

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FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pantothenic acid deficiency as a factor contributing to the development of hypertension by Schwabedal PE, Pietrzik K, Wittkowski W.(PubMed)
(2) [Pantothenic acid metabolic disorder and its relation to the change in energy processes in patients with ischemic heart disease and hypertension].[Article in Russian] by Borets VM, Ovchinnikov VA, Mironchik VV, Moĭseenok AG, Lis MA.(PubMed)

Wednesday, October 11, 2017

All About Vitamins: Vitamin B5(pantothenic acid) and Oral Contraceptive

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Women, using oral contraceptives agents may have a profound effect in reduced pantothenic acid levels during menstrual cycle, a study by renowned institute suggested.

In a total of 13 young women, ages 19-25, at the beginning and end of a 12-day confined study. 9 women using (+OCA) oral contraceptives and the other 4 were not (-OCA), entered the metabolic unit during the 1st week of their menstrual cycle and fed a constant formula diet containing 2.0 mg thiamin, 3.0 mg riboflavin, and 10 mg pantothenic acid then from 3-day dietary records, subjects were fed with 1/2 of the thiamin, riboflavin, and pantothenic acid levels, researchers found that in compared to the blood urine collected at the beginning, groups treated with +OCA group showed a significantly lower than the -OCA group.

Dr. Lewis CM, the lead author said, "At the beginning of the study, blood and urine pantothenic acid levels were significantly lower in the +OCA group than the -OCA group. These differences were no longer evident by the end of the study".

The expression showed some effects of oral contraceptive in influence to levels of pantothenic acid, but this effect can be controllable through intake of vitamin B5 rich diet during menstrual cycle.


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FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Sources


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effect of oral contraceptives agents on thiamin, riboflavin, and pantothenic acid status in young women by Lewis CM, King JC.(PubMed)

Tuesday, October 10, 2017

All About Vitamins: Vitamin B5 (Pantothenic acid) Promoted Integrity of Skin Tissue with Less Scar Formation

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

 Pantothenic acid  may have a profound effect in promotion of skin tissues including collagen in fibroblasts, a recent study by respectable institute suggested.

According to study by the Tohoku University, pantothenic acid topical administration showed a significant benefit in moisturization of the skin tissues. Deficiency of the vitamin may affect skin function in maintaining the structural integrity of the connective tissue.

In fact, the study also found that pantothenic acid depletion decreased the synthesis of keratinocyte growth factor in speedup wound healing and reduced skin tissue integration.

Noscarna, a reduced scar appearance commercial product, included vitamin B5 derivative, applied to hypertrophic scars in the rabbit ear model. showed a enormous improvements of scar healing and skin pigment in compared to non treatment group.

Truly, according to the study, the efficacy of the production in reduced scar forming is attributed to many mechanisms, including a significant reduction in scar elevation index, anterior skin and epithelial thicknesses, inflammatory cells, vessels, collagen disorganization and fibroblasts.

Dr. Lee DW , the lead author said, "(The promotion of reduced scar forming of ) Noscarn showed more favorable effects on hypertrophic scars than a commercial product, Contractubex".

More interesting, in the support of the above analysis, Dr.Ebner F postulated , " The topical use of dexpanthenol, the stable alcoholic analog of pantothenic acid, is based on good skinpenetration and high local concentrations of dexpanthenol when administered in an adequate vehicle, such as water-in-oil emulsions. Topical dexpanthenol acts like a moisturizer, improving stratum corneum hydration, reducing transepidermal water loss and maintaining skin softness and elasticity. Activation of fibroblast proliferation, which is of relevance in wound healing, has been observed both in vitro and in vivo with dexpanthenol".

According to the study, topical use of dexpanthenol in skin disorders, after 3 - 4 weeks, expressed considerably improvement of skin irritation, such as dryness of the skin, roughness, scaling, pruritus, erythema, erosion/fissures.

Taking altogether, there is no doubt that vitamin B5 may be considered as an topical ingredient used in cosmetic care for treatment of speedup skin healing with less scar formation.


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A Simple Cooking Technique That Cuts The Calories & Glycemic 
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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The effect of pantothenic acid deficiency on keratinocyte proliferation and the synthesis of keratinocyte growth factor and collagen in fibroblasts by Kobayashi D1, Kusama M, Onda M, Nakahata N.(PubMed)
(2) Effects of Noscarna™ on hypertrophic scarring in the rabbit ear model: histopathological aspects by Lee DW1, Ku SK, Cho HJ, Kim JH, Hiep TT, Han SD, Kim BG, Kang MK, Do ES, Jun JH, Jang SW, Son MW, Sohn YT, Choi HG, Yong CS, Kim JO.(PubMed)
(3) Topical use of dexpanthenol in skin disorders by Ebner F1, Heller A, Rippke F, Tausch I.(PubMed)

Monday, October 9, 2017

All About Vitamins: Pantothenic acid in Neuro Degenerative Risk

By Kyle J. Norton.

Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Deprivation of pantothenic acid (PA; vitamin B5) may associate to the early onset of neurodegenerative disease, a study bu renowned university suggested.

In a study of Wild-type and Pank2 mutant mice fed pantothenic acid-deficient diets monitored for general health, fertility and movement and compared with animals on control diets over time, showed a significant effect in manifested azoospermia (a phenotype also seen in Pank2 mice) and exhibited movement disorder with a low-lying pelvis and slow steps.

Mice fed with vitamin B5 deficit diet also effect the physical movement of the limbs caused by muscular spasm and abnormal posture in both mice groups.

According to the University of California, the result of the testing indicated that vitamin B5 deficiency may express the similar expression in neuro degernerative effect as seen in the inherited neurological disorder PKAN (pantothenate kinase-associated neurodegeneration formerly called Hallervorden-Spatz syndrome)

Further more, in the study of a mouse knock-out of the orthologous murine gene (Pank2) to enhance the understanding of the mechanisms of disease and serve as a testing ground for therapies, researchers found that overtime, murine mice manifest retinal degeneration,   progressive photoreceptor decline, decreased cell number and disruption of the outer segment and reduced pupillary constriction response.

More interestingly, in compared to wild type, experiment mice showed a significantly ameliorated fertility in displayed a condition of no sperm semen.

The reduced fertility and physical move and retinal degeneration caused by vitamin B5 deficiency 
demonstrated a similarity to in the inherited neurological disorder PKAN (pantothenate kinase-associated neurodegeneration formerly called Hallervorden-Spatz syndrome) cause ofvitamin B5 deficit, therefore, vitamin B5 may be considered as a therapeutic supplemnt in reduced risk neuro degenerative disease caused by acute vitamin B5 deficiency individuals.

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Sources
(1) Deprivation of pantothenic acid elicits a movement disorder and azoospermia in a mouse model of pantothenate kinase-associated neurodegeneration by Kuo YM1, Hayflick SJ, Gitschier J.(PubMed)
(2) Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia by Kuo YM1, Duncan JL, Westaway SK, Yang H, Nune G, Xu EY, Hayflick SJ, Gitschier J.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Friday, October 6, 2017

All About Vitamins: Pantothenic Acid in Hair Thickening

By Kyle J. Norton.
Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Vitamin B5 used combination with other ingredients may have a potential effect in protected against hair loss and treatment of hair thinning, a renowned institute study suggested.

In the study to examine the growth and quality of hair after treatment with Pantogar, another prescription (Verum-2) and placebo for four months in 60 patients with diffuse effluvium capillorum and agnogenic structural alternations of hair, group treated with Pantogar, a formula including vitamin B5 as a main ingredients, demonstrated not only improvement of quality of hair and but also reduced the retarded hair loss in compared to other groups.

More importantly, application of Pantogar were well tolerance and adverse effects could not be substantiate.

Other in the study of the ability of a novel leave-on technology combination of caffeine, niacinamide, panthenol, dimethicone and an acrylate polymer (CNPDA), showed a significant effect in thicken the hair growth in the applied area as well as increased suppleness/pliability (decreased shear modulus) and better ability to withstand force without breaking (increased break stress).

Dr, Davis MG, the lead author said, "significantly increased the diameter of individual, existing terminal scalp hair fibres by 2-5 μm, which yields an increase in the cross-sectional area of approximately 10%. Beyond the diameter increase"

The astonished result from the cosmetic treatments, may have a therapeutic effect in hair thinning individuals, but can not reverse the condition of hair loss.

Taking altogether, vitamin B5 may be considered as hair thicken ingredient used combination with with other agent for reduced risk of hair loss caused by hair thinning individuals. It is recommended that you consult your doctor before applying.


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A Simple Cooking Technique That Cuts The Calories & Glycemic 
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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
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FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Sources
(1) A novel cosmetic approach to treat thinning hair by Davis MG1, Thomas JH, van de Velde S, Boissy Y, Dawson TL Jr, Iveson R, Sutton K.(PubMed)


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.