Socrates Said," Let foods be your medicine and let medicine be your foods". Let us all practice the values of the past wisdom to build a letter living and living health while we enjoy the delicious drinks

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Thursday, March 31, 2016

The Smoothie of Carrot, Olive and Curcumin for Prevention and Treatment of Poor Vision in Conorenal syndrome

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Conorenal syndrome, also known as Mainzer-Saldino syndrome or Saldino-Mainzer disease is a medical condition of diseases involved kidney, skeletal system and eye.

Poor vision in Conorenal syndrome is a result of a progression of degeneration of photosensitive tissue of the retina in both eyes of patient since infancy.
Treatment of poor vision with natural sources may be helpful to prolong at least and prevent the destruction of the photosensitive tissues

The smoothie at least prolong and prevention of poor vision in Conorenal syndrome 
Yield: 2 servings (about 8 ounces each)

1/2 cup carrot
1 cup olive
1 tsp curcumin
1 cup rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately


The finding of a natural source for treatment of Poor Vision in Conorenal syndrome has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Cooked Sweet Potato, Olive and Grape Juice may be the next generation of natural ingredients for prevention and treatment of poor vision in Conorenal syndrome.

Carotene, an orange or red plant pigment and a precursor of vitamin A found abundantly in carrot and tomato may benefits patient with poor vision(1) in Conorenal syndrome. According to Case Western Reserve University, synthetic 9-cis-stereoisomers of vitamin A (all-trans-retinol) are especially promising agents for the fight against poor vision and blinding diseases(3).
According to the University of California, in the study of Nightblind pregnant women randomly assigned to 1 of 6 treatment groups to receive 6 d/wk for 6 wk either 850 microg retinol equivalents/d as retinyl palmitate indicated a significantly increase plasma retinol concentrations in improvement of night vision but do not difference than those who received vitamin A as liver, amaranth leaves,carrots(2).
In support the above, the London School of Hygiene & Tropical Medicine, insisted use of antioxidant vitamin or mineral supplementation such as beta-carotene, vitamin C and vitamin E may delay the progression of age-related macular degeneration disease, but more studies may be necessary to validate these claim(6).

Omega 3 fatty acid found abundantly in flax seed and olive may help improvement of poor vision(4).
Dr. Lawrenson JG and Dr. Evans JR. said, "omega 3 LCPUFA supplementation in people with AMD for periods up to five years does not reduce the risk of progression to advanced AMD or the development of moderate to severe visual loss"(5) of these may be beneficiary to the progression of vision loss of genetic mutation in Conorenal syndrome.
Furthermore, intake of Omega 3 fatty acids also showed to alleviate dry eye symptoms, decrease tear evaporation rate and improve Nelson grade in patients suffering from computer vision syndrome related dry eye(7).

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia. Its phytochemical curcumin is found effectively for treatment of eye disorder(8).
In corneal neovascularization, a leading cause for compromised vision, curcumin significant improven and prevent of corneal neovascularization by suppression in the expression of VEGF controlled by growth factors and cytokines, inflammatory cytokines,,..(9).
The Vision Research Foundation, Sankara Nethralaya study also showed that curcumin suppresses the expression and function of MDR1, the multidrug resistance-associated protein 1(10).

The effectiveness of  Carrot, Olive and Curcumin may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of poor vision in Conorenal syndrome with little or no adverse effects.

Senior who are at high risk of poor vision in Conorenal syndrome due to mutation gene should drink no more than 4 servings daily, depending to digestive toleration.

Life style and diet pattern change are necessary.




References
(1) Carrots, carotene and seeing in the dark by Smith W1, Mitchell P, Lazarus R.(PubMed)
(2) Recovery from impaired dark adaptation in nightblind pregnant Nepali women who receive small daily doses of vitamin A as amaranth leaves, carrots, goat liver, vitamin A-fortified rice, or retinyl palmitate By Haskell MJ1, Pandey P, Graham JM, Peerson JM, Shrestha RK, Brown KH.(PubMed)
(3) Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosis by Maeda T1, Perusek L, Amengual J, Babino D, Palczewski K, von Lintig J.(PubMed)
(4) Omega-3 for your eyes. Research finds DHA may help preserve your vision. [No authors listed](PubMed)
(5) Omega 3 fatty acids for preventing or slowing the progression of age-related macular degeneration by Lawrenson JG1, Evans JR.(PubMed)
(6) Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration by Evans JR1, Lawrenson JG.(PubMed)
(7) Oral omega-3 fatty acids treatment in computer vision syndrome related dry eye by Bhargava R1, Kumar P2, Phogat H3, Kaur A3, Kumar M4.(PubMed)
(8) A New Insight of Herbal Promises Against Ocular Disorders: An Occuloinformatics Approach by Srivastava P1, Tiwari A.(PubMed)
(9) Curcumin nanoparticles inhibit corneal neovascularization by Pradhan N1, Guha R2, Chowdhury S2, Nandi S2, Konar A3, Hazra S4.(PubMed)

The #CurableSmoothies for Prevention and Treatment of Diabetic Nephropathy back by Renowned Institutions

Kyle J. Norton (Scholar, and Master of nutrients) All right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Imaging of long term intake of delicious smoothies loved by many with the power of reduced risk and treatment of chronic illness with no one mentions about. In fact, it happens. Epidemiological studies with strong evidences suggested that blueberry oral administration hold a potential with therapeutic values for reduced risk of women who carry the mutation gene and treatment of breast cancer(*).

The curable smoothies are collection of recipes produced from natural sources, including organic fruits and vegetables, and some herbs which have been proven effectively for reduced risk and treatment for diseases and syndromes by scientific research of clinical trials and/or studies.

The finding of foods from natural sources has been a dream of scientists and scholars since ancient time. Socrates Said," Let foods be your medicine and let medicine be your foods". Let all of us all exercise the values of the past wisdom to build a letter living and living health while enjoining these delicious drinks.

Diabetic nephropathy is a form of progressive kidney disease caused by damage to the small veins in the kidneys' glomeruli. According to the Purdue University College of Pharmacy, antihypertensive therapy are recommendations for prevention of nephropathy in diabetic hypertensive patients(**).

The prevention of nephropathy in diabetic hypertensive patients

1. The Smoothie for reduced risk of hypertension 
The smoothie for reduced risk and treatment of  Hypertension

Yield: 2 servings (about 8 ounces each)
3/4 cup celery
3/4 cup of apple with peel
1 cup green tea drink 1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place the celery, apple with peels, green tea, in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. high blood pressure means raising pressure in your heart. If your blood pressure stays high over time it can damage the body in many ways.
Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but also induced many irreversible adverse effects, including kidney damage.

Diet rich in fruits and vegetable and reduced intake of red meat, saturated fat and trans fat has shown to attenuated risk of hypertension(1). Recent study showed that celery(2) intake used conjunction with berries(3) and green tea(4) may be the potential drink for prevention and treatment of hypertension.

Celery is a species of Apium graveolens, belongings to the family Apiaceae, cultivated all around the globe as a vegetable. According to Chronic administration of hexanic, methanolic, and aqueous-ethanolic extracts of celery seed effectively exhibited an antihypertensive activity in chronic treatment of elevated BP in tested animals(5).

Dr. Dianat M and the research team at the Ahvaz Jundishapur University of Medical Sciences said," hydro-alcoholic celery leaf extract on systolic blood pressure (SBP), heart rate (HR) and lipid profile in animals' model of hypertension induced by fructose"(6)

3‑n‑butylphthalide (NBP), an phytochemical found in celery seed used in traditional Chinese medicine exhibited significantly antihypertensive and attenuated progression of hypertensive effects through decreased oxidative stress and the expression of pro‑inflammatory cytokines(7).
Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae. It is one of the most widely cultivated tree fruits. With phytochemical flavonoids, apple and its peel inhibited angiotensin converting enzyme (ACE) in promoted the development of high blood pressure, Dr Balasuriya N and Dr. Rupasinghe HP. Suggested(8)According to the Mount Sinai School of Medicine, "Flavonoid (found abundantly in fruits and vegetable)(10) intake has been inversely associated with mortality from coronary heart disease and stroke,..... Lowering blood pressure through increased dietary consumption of dietary antioxidants(such as flavonoid) may decrease the rate of end-organ damage that is secondary to hypertension"(9).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

Epigallocatechin-3-O-gallate (EGCG), the main polyphenol presence in green tea is best known for its antioxidant and anti inflammatory effect. In animal model, the phytochemical exhibited anti hypertensive and progressive activity through reduction of oxidative stress in paraventricular nucleus of hypothalamus (PVN), the Xi'an Jiaotong University Health Science Center study showed(11).

Dr. Yarmolinsky J and the research team at the Federal University of Rio Grande do Sul, suggested that, intake of tea are shown to reduce blood pressure in individuals within prehypertensive and hypertensive ranges in the review of all relevant studies published from 1946 to September 27, 2013.(12).

Furthermore, green tea extract (GTE) inhibited the oxidative stress and ingiotensin (Ang) II induces endothelial dysfunction (ED) causes of hypertension through scavenging of superoxide anion generation, the University of Padova, insisted(13).

People who are at increased risk of hypertension due to family history, Diabetic nephropathy,... .....should drink at least one cup daily and people with chronic hypertension should drink the juices at least 3 times a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

2. The smoothie for reduced risk and treatment of diabetes
Yield: 2 servings (about 8 ounces each)

1 3/4 cup whole food papaya
1/4 tsp cinnamon
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)
1. Place whole food papaya, cinnamon and green tea drink in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of diabetes has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases,diabetes is also caused by allergic reactions of cells in the immune system

Cinnamon, a kitchen spicy in many cultures, may have gained many believers, including medical professions because of its anti diabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects. According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce the blood sugar significantly with little or no adverse effects.

The herb has been use in herbal and traditional medicine as anti-fungal and bacteria level to improve reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(14).

According to the 2011 statistic from National Diabetes InformationClearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, had diabetes in 2010, about 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010 and approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.

In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, showed a significant reduction of blood triglyceride levels in the low-dose group, after 3 months of oral administration(15)

Some researchers suggested that cinnamon extract may improve fasting blood glucose levels and glucose tolerance without altering the insulin secretion, through lower triglyceride and increased liver glycogen content and improved insulin action in liver tissues(16).

Dr. Kim SH and Dr. Choung SY. told PubMed "The effect of cinnamon in significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR(in regulation of metabolism (carbohydrate, lipid, protein))-medicated glucose and lipid metabolism"(17)

In support of the above, chromium(Cr) and polyphenols found in cinnamon(Cinnamomon cassia) indicated a improvement of glucose, insulin, cholesterol and HbA1c(Glucose lab test) in patients with type 2 diabetesfollowing Cr supplementation, in a double-blind placebo-controlled study(20).

Unfortunately, according to the Western University of Health Sciences, consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose, but insisted that high degree of heterogeneity may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(18)

A randomized clinical trial in which 70 Patients with type II diabetesassigned randomly two groups (35 in cinnamon and 35 in placebo group for the testing of the effect of cinnamon on the glucose level in blood, indicated an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(19).


People with Type II Diabetes may also be thinking to add whole food papaya into their diet. the recent study suggested(20) ,
The finding not only showed the effectiveness of unripe pawpaw fruit (Carica papaya) in inhibition α-amylase, α-glucosidase, but also induced lipid peroxidation in a dose-dependent manner, in rat pancreas(20).
The key enzymes of α-amylase, α-glucosidase, involved in the digestion of carbohydrates, have been linked to onset of type 2 diabetes. Inhibition of these enzymes can significantly reduce the post-prandial increase of blood glucose and have been considered by therapists in use for management of blood glucose level in type 2 diabetic and borderline patients(21).

In streptozotocin-induced diabetic rats study, the aqueous extract of leaves of C. papaya administered strongly controlled blood glucose levels(22), through prevention of hepatocyte disruption, as well as accumulation of glycogen and lipids via its hypoglycemic and antioxidant effect(23)


In a new study, conducted by the researchers at the Davis Heart and Lung Research Institute, fermented papaya preparation was tested whether it improves dermal wound healing outcomes in adult diabetic mice by preventing the risk of infections(24).
The result was astonishing, the fermentation not only up regulated the Sp1 DNA binding activity(modulating the cellular response to DNA damage) in Peripheral blood mononuclear cells (PBMC) but also the protein and mRNA expression of Rac2(regulates a number of cellular functions)(24).

A randomized controlled clinical trial conducted at the Cardiac Centre, ANDI Centre of Excellence for Biomedical and Biomaterials Research and Department of Biosciences University of Mauritius, suggested that oral administration of 6g FPP®/day for a period of 14 weeks could improve the general health status of several organs targeted by oxidative stress duringdiabetes and suggested that the supplement may be used in the management the complications of diabetes such as cardiovascular disease, neurological disease and other conditions worsened by overt inflammation and oxidative stress(25).
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

Green tea has ling been known for its effect on treatment of diabetes in ancient Chinese literature, probably due to green tea phytochemical polyphenols(26).Dr. Solayman M and the research tea at the Universiti Sains Malaysia said, "Natural products containing high polyphenol levels can control carbohydrate metabolism by various mechanisms, such as protecting and restoring beta-cell integrity, enhancing insulin releasing activity, and increasing cellular glucose uptake"(27).

In a total of 17,413 persons (6727 men and 10,686 women; 49% of the original study population) who were 40 to 65 years of age, daily drinking of green tea reduced risk of diabetes by 33%, especially in women and in overweight men(13).Furthermore, intake of green tea of 150 ml green tea, three times a day for four weeks, has positive effect on insulin resistance and certain lipoproteins in type 2 DM, according to the Shahid Sadoughi University of Medical Science(28).

People who are at increased risk of diabetes due to family history, gene mutation, obesity, Diabetic nephropathy, ....should drink at least one serving daily and people with diabetes should drink no more than 4 servings a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

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References
(**) Antihypertensive therapy for the prevention of nephropathy in diabetic hypertensive patients by Isaacs AN1,2, Vincent A1,3.(PubMed)
(1) Fruit and Vegetable Consumption and the Incidence of Hypertension in Three Prospective Cohort Studies by Borgi L1, Muraki I2, Satija A2, Willett WC2, Rimm EB2, Forman JP2.(PubMed)
(2) The effect of hydro-alcoholic celery (Apiumgraveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by fructose by Dianat M1, Veisi A1, Ahangarpour A1, Fathi Moghaddam H1.(PubMed)
(3) Flavonoids from fruit and vegetables: a focus on cardiovascular risk factors by Toh JY1, Tan VM, Lim PC, Lim ST, Chong MF.(PubMed)
(4) Decaffeinated green tea extract improves hypertension and insulin resistance in a rat model of metabolic syndrome by Ihm SH1, Jang SW, Kim OR, Chang K, Oak MH, Lee JO, Lim DY, Kim JH.(PubMed)
(5) Antihypertensive effect of celery seed on rat blood pressure in chronic administration by Moghadam MH1, Imenshahidi M, Mohajeri SA.(PubMed)
(6) The effect of hydro-alcoholic celery (Apiumgraveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by fructose by Dianat M1, Veisi A1, Ahangarpour A1, Fathi Moghaddam H1.(PubMed)
(7) Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats by Zhu J1, Zhang Y1, Yang C1.(PubMed)
(8) Antihypertensive properties of flavonoid-rich apple peel extract by Balasuriya N1, Rupasinghe HP.(PubMed)
(9) Dietary flavonoids and hypertension: is there a link? by Moline J1, Bukharovich IF, Wolff MS, Phillips R.(PubMed)
(10) Antihypertensive effects of the flavonoid quercetin by Perez-Vizcaino F1, Duarte J, Jimenez R, Santos-Buelga C, Osuna A.(PubMed)
(11) Paraventricular Nucleus Infusion of Epigallocatechin-3-O-Gallate Improves Renovascular Hypertension by Yi QY1, Qi J, Yu XJ, Li HB, Zhang Y, Su Q, Shi T, Zhang DM, Guo J, Feng ZP, Wang ML, Zhu GQ, Liu JJ, Shi XL, Kang YM.(PubMed)
(12) Effect of tea on blood pressure for secondary prevention of cardiovascular disease: a systematic review and meta-analysis of randomized controlled trials by Yarmolinsky J1, Gon G2, Edwards P2.(PubMed)
(13) Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts by Antonello M1, Montemurro D, Bolognesi M, Di Pascoli M, Piva A, Grego F, Sticchi D, Giuliani L, Garbisa S, Rossi GP.(PubMed)
(14) @Popular Herbs -Cinnamon
(15) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(16) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(17) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(18) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(19) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)(7) Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya) by Oboh G, Olabiyi AA, Akinyemi AJ, Ademiluyi AO.(PubMed)
(20) Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update by Tundis R1, Loizzo MR, Menichini F.(PubMed)
(21) Antihyperglycemic and hypolipidemic activities of aqueous extract ofCarica papaya Linn. leaves in alloxan-induced diabetic rats by Maniyar Y, Bhixavatimath P.(PubMed)
(22) Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats by Juárez-Rojop IE1, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T, Bermúdez-Ocaña DY.(PubMed)
(23) Correction of aberrant NADPH oxidase activity in blood-derived mononuclear cells from type II diabetes mellitus patients by a naturally fermented papaya preparation by Dickerson R1, Deshpande B, Gnyawali U, Lynch D, Gordillo GM, Schuster D, Osei K, Roy S.(PubMed)
(24) Effects of a short term supplementation of a fermented papaya preparation on biomarkers of diabetes mellitus in a randomized Mauritian population by Somanah J1, Aruoma OI, Gunness TK, Kowelssur S, Dambala V, Murad F, Googoolye K, Daus D, Indelicato J, Bourdon E, Bahorun T.(PubMed)
(25) The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults by Iso H1, Date C, Wakai K, Fukui M, Tamakoshi A; JACC Study Group(PubMed)
(26) Polyphenols: Potential Future Arsenals in the Treatment of Diabetes by Solayman M, Ali Y, Alam F, Islam MA, Alam N, Khalil MI, Gan SH1(PubMed)
(27) Polyphenols: Potential Future Arsenals in the Treatment of Diabetes by Solayman M, Ali Y, Alam F, Islam MA, Alam N, Khalil MI, Gan SH1.(PubMed)
(28) The Effect of Green Tea versus Sour Tea on Insulin Resistance, Lipids Profiles and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial by Mozaffari-Khosravi H1, Ahadi Z1, Fallah Tafti M2.(PubMed)

Wednesday, March 30, 2016

The #CurableSmoothie of Tomato, Sweet Potato and Dulse for Prevention and Treatment of Fibrocystic breast disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced risk and treatment of Fibrocystic breast disease
Yield: 2 serving (about 8 ounce each)
3/4 cup tomato
1/4 cup sweet potato
1/2 dulse
1 cup rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for improvement of Fibrocystic breast disease   is considered as a dream of many scientist. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center. Some even produce conflicted results in second and further studies.

Fibrocystic breast disease also known as fibrocystic breast condition is defined as a condition in which cysts, and noncancerous lump found in the breast tissue as result of hormonal change from the menstrual cycle. Fibrocystic breast diseases sometime cause pain and discomfort which affects approximately 30-60% of women.

Update reports from numbers of well known institutions insisted, intake of tomato(1) with high amount carotenoids, may be the next generation ingredient to be used on prevention and treatment of Fibrocystic breast disease. According to the the retinol and RA isomers may associate to prevention and treatment of Fibrocystic breast disease.(1). The researchers said, "11-cis RA in breast adipose tissue was significantly lower in the breast cancer patients than those of benign breast disease patients and it was associated with the stage of malignancy"
According to Dr. Band PR and colleagues, vitamin A may be used for treatment at dose-depend of benign breast disease (BBD) as patient produce a positive and complete or partial responses at 3 months of application(2).
In fact, Dr. Pasquali D and research team at the Seconda Universitá di Napoli, said, "Retinoids seem to act as agents of chemoprevention and differentiation in breast diseases, as both malignant and benign breast tissues may be target for retinoids, justifying the use of natural and synthetic vitamin A derivatives in the chemoprevention of breast disease"(3).

Sweet potato, containing highest amount of vitamin E in comparison to other vegetables, is a large, starchy, sweet tasting tuberous roots vegetable, genus Ipomoea, belongings to the family Convolvulaceae. According to Dr. Horner NK and Dr. Lampe JW. application of vitamin E may be used for treatment of fibrocystic breast conditions together with addition of diet pattern change(4).
The collaborative study by University of L'Aquila--University of Rome suggested that vitamin A and E reduced or resolved clinical palpable breast findings (with pain, tension, nodularity and instrumental patterns) in a group of women (double-blind trial) affected by breast dysplasia(5).
Fibrocystic breast disease , Alexander Mostovoy, H.D., D.H.M.S., BCCT said, "has provided dramatic results in controlling cystic mastitis, take 600 IU daily of d- alpha tocopherol. Vitamin E-based antioxidants are found in rice bran, palm fruit, barley, and wheat germ"(6).

Dulse, a red seaweed of genus Palmaria, belong to Family Palmariaceae grows attached to rocks by a "holdfast" in the North Atlantic and Northwest Pacific. The sea vegetable may be used for prevention and treatment of fibrocystic breast disease due to the presence of iodine(7).
Dr. Ghent WR and colleagues at the Queen's University said, " The fibrocystic breast reacts differently to sodium iodide, protein-bound iodide and molecular iodine. Molecular iodine is nonthyrotropic and was the most beneficial"(8).
In animal model, dietary restriction and chemical blockade of iodine causes histopathologic changes in peripubertal female rat breasts, leading to noticeable calcospherite deposition, intralobular fibrosis, and cystic changes resembling human fibrocystic disease, according to the study of 42-week-old rats(9).

The smoothie of Tomato, Sweet Potato and Dusle  may hold a key in further studies in production of effective natural ingredients for prevention and treatment of fibrocystic breast disease without inducing adverse effects.

Women who are at increased risk of fibrocystic breast disease, due to family history,... should drink at least one cup daily. Women with fibrocystic breast disease, should drink no more than 4 servings daily depending to the digestive toleration.


References
(1) Retinoids, carotenoids, and tocopherols in breast adipose tissue and serum of benign breast disease and breastcancer patients by Shim E1, Yeum KJ, Tang G, Ahn SH, Hwang J, Lee-Kim YC.(PubMed)
(2) Treatment of benign breast disease with vitamin A. by Band PR, Deschamps M, Falardeau M, Ladouceur J, Cote J.(PubMed)
(3) Retinoic acid receptors alpha, beta and gamma, and cellular retinol binding protein-I expression in breastfibrocystic disease and cancer by Pasquali D1, Bellastella A, Valente A, Botti G, Capasso I, del Vecchio S, Salvatore M, Colantuoni V, Sinisi AA.(PubMed)
(4) Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness by Horner NK1, Lampe JW.(PubMed)
(5) [Clinical use of vitamin A and E in gynecology].[Article in Italian] by Pozzi V, Luciani S, Marino S, Nusiner MP.(PubMed)
(6) Fibrocystic breast disease  by Alexander Mostovoy, H.D., D.H.M.S., BCCT at Thermography clinic Inc.
(7) Iodine: deficiency and therapeutic considerations. by Patrick L1.(PubMed)
(8) Iodine replacement in fibrocystic disease of the breast. by Ghent WR1, Eskin BA, Low DA, Hill LP.(PubMed)
(9) Age-related changes resembling fibrocystic disease in iodine-blocked rat breasts by Krouse TB, Eskin BA, Mobini J.(PubMed)

The Smoothie of Cantaloupe and Juar tea for Prevention and Treatment of Skeletal Abnormalities in Conorenal syndrome

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie at least prolong and prevention of Skeletal Abnormalitie sin Conorenal syndrome 
Yield: 2 servings (about 8 ounces each)

1 1/2 cup cantaloupe
1 cup of Juar tea

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately


The finding of a natural source for treatment of Skeletal Abnormalities in Conorenal syndrome has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, cantaloupe and Juar tea may be the next generation of natural ingredients for prevention and treatment of Skeletal Abnormalities in Conorenal syndrome.

Conorenal syndrome, also known as Mainzer-Saldino syndrome or Saldino-Mainzer disease is a medical condition of diseases involved kidney, skeletal system and eye with the same genetic mutation.
Skeletal Abnormalities in Conorenal syndrome is a condition of bone abnormalities observed in multiple bones as well as inducing craniosynostosis, the short stature.

 Cantaloupe is a species in the family Cucurbitaceae, originally cultivated by the Egytian (The European cantaloupe) and by India and Africa (The North American cantaloupe).

Antioxidant enzyme extracellular superoxide dismutase (EC-SOD),commercially obtained from cantaloupe and in regulation of ROS-mediated tissue damage(1) plays an important antioxidant defense function in skeletal muscle against cardiac cachexia and exercise intolerance in congestive heart failure(CHF)(2).
According to the study led by the University of Virginia, the antioxidant enzyme also enhanced by exercise training in expression of skeletal muscle and elicitation of positive health outcomes in individuals through ameliorated oxidative stress(3).

Juar tea, type of black tea native to African,  according to the National Defense Medical College, Saitama, Japan, Consumption of polyphenol-rich juar tea increases endothelium-bound extracellular superoxide dismutase levels (EC-SOD) of that may be beneficiary to patient with Conorenal syndrome induced skeletal Abnormalities(4)(5).

The effectiveness of   Cantaloupe and Juar tea  may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Skeletal Abnormalities in Conorenal syndrome with little or no adverse effects.

People who are at high risk of Skeletal Abnormalities in Conorenal syndrome due to mutation gene should drink no more than 4 servings daily, depending to digestive toleration.

Life style and diet pattern change are necessary.


References
(1) Extracellular superoxide dismutase in biology and medicine by Fattman CL1, Schaefer LM, Oury TD.(PubMed)
(2) Extracellular superoxide dismutase ameliorates skeletal muscle abnormalities, cachexia, and exercise intolerance in mice with congestive heart failure by Okutsu M1, Call JA1, Lira VA1, Zhang M1, Donet JA1, French BA1, Martin KS1, Peirce-Cottler SM1, Rembold CM1, Annex BH1, Yan Z2.(PubMed)
(3) Enhanced skeletal muscle expression of extracellular superoxide dismutase mitigates streptozotocin-induced diabetic cardiomyopathy by reducing oxidative stress and aberrant cell signaling. by Call JA1, Chain KH1, Martin KS1, Lira VA1, Okutsu M1, Zhang M1, Yan Z2.(PubMed)
(4) Consumption of polyphenol-rich juar tea increases endothelium-bound extracellular superoxide dismutase levels in men with metabolic syndrome: link with LDL oxidizability by Uto-Kondo H1, Ayaori M, Kishimoto Y, Adachi T, Takiguchi S, Yakushiji E, Sasaki M, Komatsu T, Kondo K, Ikewaki K.(PubMed)
(5) Superoxide Dismutase supplement pill SOD benefit and risk, by Ray Sahelian, M.D

Tuesday, March 29, 2016

The #CurableSmoothie of Orange, Spinach and Grape Juice for Prevention and Treatment of Breast Hematoma

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The curable smoothie for reduced risk and treatment of Breast hematoma
1  cup of organic orange
1/2 spinach
1 cup organic grape juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding of a natural source for reduced risk and treatment of  Breast hematoma has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Scientists in some well known institutions may have found the therapeutic and potential ingredients from natural sources(such as Ginger, Alfalfa Sprout  and Orange) for reduced risk and treatment of Breast hematoma.

Breast hematoma is a collection of blood due to bleeding within the breast. According to the Penn State Milton S. Hershey Medical Center, "The probability of development of a non-clinically significant hematoma was 21.6% for patients taking antithrombotics and 13.0% for those not taking antithrombotics"(1).

Vitamin K, found abundantly in spinach has exerted its coagulation effects in reduced risk of (subdural) hematoma, in a randomized trials identified from the Cochrane Central Register of Controlled Trials(2).
The Fuwai Hospital joint study also suggested, the favorite uninterrupted vitamin K antagonists (VKAs), in comparison to anticoagulation in catheter ablation (CA) of atrial fibrillation (AF) in occurrence of stroke or transient ischemic attacks and major bleeding in test subjects(3).
Dr. Levi M said, "Bleeding is the most important adverse effect of antithrombotic treatment and may be a major cause of morbidity, longstanding debilitation, and even mortality....... can be neutralized by the administration of vitamin K or prothrombin complex concentrates"(4).

Vitamin C, a water soluble vitamin found in orange may also benefit women with breast hematoma by preventing the breaking off  capillaries, the small vessels in the breast inducing bleeding(5).
According to the University Clinic Muenster, Vitamin C was shown to be cerebroprotective in several animal models of stroke, through the expression and transport activity of SVCT2, :key proteins for vitamin C uptake. in brain capillary endothelial cells after transhwaient ischemia in mice(6).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape may also reduced risk of complications caused by severe hemorrhagic injury, including the Lung(8), intestines(9), cystitis(10),.....through both pro and anti-inflammatory pathways(7).

The effectiveness of Orange, Spinach and Grape Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for for Reduced Risk and treatment of Breast hematoma with little or no adverse effects.

Women who are at increased risk of Breast hematoma due to family history, aging,.....may drink at least one serving daily and women with  Breast hematoma may drink as much as they can, depending to the digestive toleration.
Life style and dietary patter change are recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

References
(1) Hematoma formation during breast core needle biopsy in women taking antithrombotic therapy by Chetlen AL1, Kasales C, Mack J, Schetter S, Zhu J.(PubMed)
(2) Vitamin K antagonists and risk of subdural hematoma: meta-analysis of randomized clinical trials by Connolly BJ1, Pearce LA1, Hart RG2.(PubMed)
(3) Meta-Analysis of Efficacy and Safety of New Oral Anticoagulants Compared With UninterruptedVitamin K Antagonists in Patients Undergoing Catheter Ablation for Atrial Fibrillation. by Wu S1, Yang YM2, Zhu J1, Wan HB1, Wang J1, Zhang H1, Shao XH1.(PubMed)
(4) Emergency Reversal Strategies for Anticoagulation and Platelet Disorders by Levi M1.(PubMed)
(5) High-dose vitamin C treatment reduces capillary leakage after burn plasma transfer in rats by Kremer T1, Harenberg P, Hernekamp F, Riedel K, Gebhardt MM, Germann G, Heitmann C, Walther A.(PubMed)
(6) Sodium-dependent vitamin C transporter 2 (SVCT2) expression and activity in brain capillaryendothelial cells after transient ischemia in mice by Gess B1, Sevimli S, Strecker JK, Young P, Schäbitz WR.(PubMed)
(7) Alteration of cytokine profile following hemorrhagic shock by Lu S1, Aguilar A1, Subramani K1, Poulose N1, Ayub A1, Raju R2.(PubMed)
(8) Dihydro-Resveratrol Ameliorates Lung Injury in Rats with Cerulein-Induced Acute Pancreatitis by Lin ZS1,2, Ku CF1, Guan YF1, Xiao HT1, Shi XK1, Wang HQ2, Bian ZX1, Tsang SW1,3, Zhang HJ1.(PubMed)
(9) Effects of resveratrol on methotrexate-induced intestinal injury by Yulug E, Turedi S, Alver A, Turedi S, Kahraman C.(PubMed)
(10) Prevention of cyclophosphamide-induced hemorrhagic cystitis by resveratrol: a comparative experimental study with mesna by Keles I1, Bozkurt MF, Cemek M, Karalar M, Hazini A, Alpdagtas S, Keles H, Yildiz T, Ceylan C, Buyukokuroglu ME.(PubMed)

The #CurableSmoothie of Green Tea, Curcumin and Grape for Prevention and Treatment of Cervicitis

Kyle J. Norton(Scholar, Master of Nutrient, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Cervicitis 
Yield: 2 servings (about 8 ounces each)
1 1/2  cups grape
1 tsp curcumin
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding of a natural source for reduced risk and treatment of cervicitis to replace the conventional medicine has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.
Cervicitis is an inflammation of the cervix.
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.
According to the The Catholic University of Korea, green tea extracts (polyphenon E; poly E and (-)-epigallocatechin-3-gallate [EGCG]) exhibited anti human papilloma virus (HPV) infected cervical lesions at a a 200 mg of poly E taken orally every day for eight to 12 weeks(1).
The phytochemicals of epigallocatechin gallate and polyphenols E also inhibited immortalized HPV-immortalized cervical epithelial cells and cancer cell growth. induced apoptosis through cell cycle change, according Guangxi Medical University(2).

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia. Its phytochemical curcumin can stimulate prevention of multiple sexually transmitted infections of cervix caused by HIV (human immunodeficiency virus), HSV (herpes simplex virus) and HPV (human papilloma virus)(3).
According to the Air Force General Hospital of People's Liberation Army, curcumin induced apoptosis of HPV-positive human cervical cancer cells via the anti inflammatory/cellular tumor antigen NF-κB-p53-caspase-3 pathway(4).
In a phase II randomized controlled study,curcumin and curcumin containing polyherbal preparations have demonstrated anti-microbial and anti- viral properties against cervical human papillomavirus (HPV) infection(5).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in grape, etc. may also expressed immune modulating effects(6) against human papillomavirus (HPV)induced  inflammation(7) and malignant progression in neoplasms(8).

The effectiveness of  Green Tea, Curcumin and Grape may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for for Reduced Risk of Consequences of  cervicitis with little or no adverse effects.

Women who are at increased risk of Cervicitis due to sexual active,.... should take 1 - 2 servings daily and women with Cervicitis should take as much as they can depending to the digestive toleration.
Life style and dietary patter change are recommended.


References
(1) Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions by Ahn WS1, Yoo J, Huh SW, Kim CK, Lee JM, Namkoong SE, Bae SM, Lee IP.(PubMed)
(2) Green tea compound in chemoprevention of cervical cancer by Zou C1, Liu H, Feugang JM, Hao Z, Chow HH, Garcia F.(PubMed)
(3) Natural polyphenols: potential in the prevention of sexually transmitted viral infections by Date AA1, Destache CJ2.(PubMed)
(4) Curcumin improves the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cells via the NF-κB-p53-caspase-3 pathway by Dang YP1, Yuan XY1, Tian R1, Li DG1, Liu W1.(PubMed)
(5) Clearance of cervical human papillomavirus infection by topical application of curcumin andcurcumin containing polyherbal cream: a phase II randomized controlled study by Basu P1, Dutta S, Begum R, Mittal S, Dutta PD, Bharti AC, Panda CK, Biswas J, Dey B, Talwar GP, Das BC.(PubMed)
(6) The enhancement of immune function and activation of NF-κB by resveratrol-treatment in immunosuppressive mice by Lai X1, Pei Q2, Song X1, Zhou X1, Yin Z3, Jia R4, Zou Y1, Li L1, Yue G5, Liang X1, Yin L1, Lv C1, Jing B1(PubMed)
(7) Regulation of immune responses to HPV infection and during HPV-directed immunotherapy by Bhat P1, Mattarollo SR, Gosmann C, Frazer IH, Leggatt GR.(PubMed)
(8) The role of human papilloma virus (HPV) infection in non-anogenital cancer and the promise of immunotherapy: a review by Cobos C1, Figueroa JA, Mirandola L, Colombo M, Summers G, Figueroa A, Aulakh A, Konala V, Verma R, Riaz J, Wade R, Saadeh C,Rahman RL, Pandey A, Radhi S, Nguyen DD, Jenkins M, Chiriva-Internati M, Cobos E.(PubMed)

The #CurableSmoothie of Cherries, Ginger and Peppermint for Prevention and Treatment of chronic pain in Autosomal recessive polycystic kidney disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The finding of a natural source for treatment of Autosomal recessive polycystic kidney disease has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Autosomal recessive polycystic kidney disease is an inherited diseases(Mutations in the PKHD1)causing abnormal functions of liver and reno inducing morbidity and mortality in children.
Until today, there is no cure, treatment options for autosomal recessive polycystic kidney disease, depending to complications, such as chronic pain.


The smoothie for people with chronic pain in Autosomal recessive polycystic kidney disease
Yield: 2 serving (about 8 ounce each)
1 1/2 cups cherries cups pineapple
1 slice of ginger root
1 cup of peppermint herbal tea

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Cherries(1), ginger(4) and peppermint(7) may be the next combination of therapeutic ingredients as pain reliever for treatment of chronic pain in patients with autosomal recessive polycystic kidney disease.

Cherry, a fleshy drupe, is the fruit of many plants of the genus Prunus cultivated all over the world for commercial profit due to its health potential.

In a randomized double-blind crossover study of 58 non-diabetic patients , oral administration of cherry juice improved the Western Ontario McMaster Osteoarthritis Index (WOMAC) scores, inducing the symptom relief, including pain for patients with mild to moderate knee Osteoarthritis, through lowering the C-reactive protein CRP levels(1).According to the Oregon Health & Science University, the study of fifty-four healthy runners with ingest of 355 mL bottles of tart cherry juice twice daily for 7 day, during a strenuous running event can minimize post-run muscle pain(3).

Dr. Kuehl KS said, "Tart cherries appear to possess similar effectiveness in treating the inflammatory reaction seen in both acute and chronicpain syndromes encountered among athletes and non-athletes with chronic inflammatory disease")2) of that may be used as antioxidant and anti-inflammatory ingredient on prevention, treatment, and recovery of soft tissue injury and pain.

Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In primary dysmenorrhea patient, ginger is effective on pain relief without inducing adverse effects and may be used as an alternative treatment for primary dysmenorrhea, according to the Mazandaran University of Medical Sciences(4) and treatment of ginger in students with primary dysmenorrhea for 5 days also showed a statistically significant effect on relieving intensity and duration of pain, the Shahed University, study suggested(5).
Furthermore, in osteoarthritic patient, Dr. Therkleson T said," ginger therapy activated a marked relief of osteoarthritis symptoms that progressively improved over the 24 weeks, with no negative effects reported. Ginger therapy needs to be considered by nurses caring for specific personality types with osteoarthritis"(6).

Peppermint is a hybrid mint with small purple or white flowers and downy leaves, in the genus Mentha, belongings to the family Lamiaceae, native to to Europe, used in folk medicine as analgesic, antiseptic, antispasmodic, decongestant, agent and to relieve gas, nausea, and stomach pain due to an irritable bowel, intestinal cramps, or indigestion, infecttion, etc

According to the Translational Research Center for Gastrointestinal Disorders (TARGID), peppermint oil, with antispasmodics may be considered as the first-line treatment for abdominal pain in patient with irritable bowel syndrome (IBS)(7).
Menthol, the cooling natural product of peppermint,according to the study conducted by Yale University School of Medicine, is widely used for the relief of acute and inflammatory pain in sports injuries, arthritis, and other painful conditions, through activating the methol induced the sensation of cooling(8).
Dr. Shen YH and Dr. Nahas R. said," Peppermint oil alleviates IBS symptoms, including abdominal pain" and "several complementary and alternative therapies can be recommended as part of an evidence-based approach to the treatment of IBS; these might provide patients with satisfactory relief and improve the therapeutic alliance"(9).
In the 76-year-old woman whose pain had been resistant to standard therapies, application of neat peppermint oil showed to immediately improve in her pain with persistence for 4-6 hours after application of the oil(10).

Taking altogether, People with Chronic Pain due to autosomal recessive polycystic kidney diseasen should drink the smoothie as much as they can, depending to digestive and liver toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca



References
(1) Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee by Schumacher HR1, Pullman-Mooar S, Gupta SR, Dinnella JE, Kim R, McHugh MP.(PubMed)
(2) Cherry juice targets antioxidant potential and pain relief by Kuehl KS1.(PubMed)
(3) Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial by Kuehl KS1, Perrier ET, Elliot DL, Chesnutt JC.(PubMed)
(4) The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial by Shirvani MA1, Motahari-Tabari N, Alipour A.(PubMed)
(5) Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial by Rahnama P1, Montazeri A, Huseini HF, Kianbakht S, Naseri M.(PubMed)
(6) Ginger Therapy for Osteoarthritis: A Typical Case by Therkleson T1.(PubMed)
(7) Treatment of abdominal pain in irritable bowel syndrome by Vanuytsel T1, Tack JF, Boeckxstaens GE.(PubMed)
(8) TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain by Liu B1, Fan L, Balakrishna S, Sui A, Morris JB, Jordt SE.(PubMed)
(9) Complementary and alternative medicine for treatment of irritable bowel syndrome by Shen YH1, Nahas R.(PubMed)
(10) A novel treatment of postherpetic neuralgia using peppermint oil by Davies SJ1, Harding LM, Baranowski AP.(PubMed)

The #CurableSmoothie of Kidney Bean, Avocado and Apricot for Prevention and Treatment of Dent's Disease

Kyle J. Norton (Scholar, and Master of nutrients) All right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Imaging of long term intake of delicious smoothies loved by many with the power of reduced risk and treatment of chronic illness with no one mentions about. In fact, it happens. Epidemiological studies with strong evidences suggested that blueberry oral administration hold a potential with therapeutic values for reduced risk of women who carry the mutation gene and treatment of breast cancer(*).

The curable smoothies are collection of recipes produced from natural sources, including organic fruits and vegetables, and some herbs which have been proven effectively for reduced risk and treatment for diseases and syndromes by scientific research of clinical trials and/or studies.

The finding of foods from natural sources has been a dream of scientists and scholars since ancient time. Socrates Said," Let foods be your medicine and let medicine be your foods". Let all of us all exercise the values of the past wisdom to build a letter living and living health while enjoining these delicious drinks.

The smoothie for prevention and treatment of Dent's disease

Yield: 2 servings (about 8 ounces each)
1/2 cup kidney bean
1 cup avocado
1 cup apricot juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Recent studies by some renowned institutions suggested that Kidney bean, avocado and apricot may be the next generation of ingredient extracted from natural sources for reduced risk and treatment of Dent's disease.

Dent's disease is a genetic mutation of reno disease, affecting the proximal renal tubules of the kidney in male population mostly.
Potassium citrate, a form of potassium often found naturally in foods, such as kidney bean, avocado and apricot, etc. at 3 mEq/kg/day for 2 months effectively normalized serum bicarbonate and decreased the risk of calcium oxalate stone in children of Dent's disease(1).
According to the Mahidol University, monitoring of urinary calcium-to-creatinine ratio or citrate-to-creatinine ratio is necessary to ensure adequate amount intake of potassium citrate supplementation for prevention of urinary saturation for calcium oxalate(2).
Dr. Preminger GM and professors at the Southwestern Medical School said, "Potassium citrate caused a decrease in urinary calcium and a significant increase in urinary citrate that resulted in a significant decrease in the urinary saturation of calcium oxalate"(3).

The effectiveness of Kidney Bean, Avocado and Apricot may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Dent's disease with little or no adverse effects.

People who are at high risk of Dent's disease due to genetic mutation should drink no more than 4 servings daily, depending to digestive toleration.
Life style and diet pattern change are necessary.


References
(1) The optimal dose of potassium citrate in the treatment of children with distal renal tubular acidosis by Tapaneya-Olarn W1, Khositseth S, Tapaneya-Olarn C, Teerakarnjana N, Chaichanajarernkul U, Stitchantrakul W, Petchthong T.(PubMed)
(2) Dosage of potassium citrate in the correction of urinary abnormalities in pediatric distal renal tubular acidosis patients By Domrongkitchaiporn S1, Khositseth S, Stitchantrakul W, Tapaneya-olarn W, Radinahamed P.(PubMed)
(3) Alkali action on the urinary crystallization of calcium salts: contrasting responses to sodium citrate and potassium citrate by Preminger GM1, Sakhaee K, Pak CY.(PubMed)

Monday, March 28, 2016

The #CurableSmoothie of formula RRF and Flax Seed for Reduced Symptoms and Treatment of Perimenopause

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced symptoms and treatment of Perimenopause 
Yield: 2 serving (about 8 ounce each)
1 gram of formula RRF(you cam buy them in any Chinese herbal store)
1/2 cup of flax seed
1 cup of grape
1 cup of rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for reduced symptoms and treatment of Perimenopause  is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine.
Unfortunately, many compounds found effective in initial studying failed to confirm the potentials in large sample size and multi center.

Recent studies suggested that scientist in some research centers have found the naturally potential ingredients, from Radix Astragali (RA), Radix Angelicae Sinensis (RAS) and Folium Epimedii (FE), three of the extensively applied herbs among traditional Chinese medicines for gynecological disorders(1), including symptoms of Perimenopause.

Long-term treatment of RRF formula exhibited estrogenic properties, inhibited age-associated egeneration may be considered as an alternative/complementary medicine in relieving perimenopausal symptoms(1), according to the joint study lead by the Guangzhou University of Chinese Medicine.

Huang Qi or Bei Qi is also known as Astragalus root. The sweet herb has been used as diuretic agent and to lower blood pressure, increase blood pressure, lessens proteinuria, improve endurance, protect liver function, regulate blood sugar, etc.

In natural aging animal study, Radix Astragali used conjuction with Radix Angelicae Sinensis, and Folium Epimedii in formula RRF, expressed a a positive regulation on the estrogen imbalance and neurotransmitter disorder in restoring reproductive organ degeneration and skeleton deterioration in perimenopausal rats(2).

According to the Guangzhou University Town, RRF also enhanced estradiol (E(2) synthese while diminished the elevated serum FSH and LH levels, attenuated osteoporosis by elevating the BMD levels of total body and bone trabeculae degradation of which induced a capable of acting at multiple targets in the protection and treatment of perimenopausal disorders in midlife women(3).

Furthermore, RRF on study of immunological function, RRF also displayed a relatively wide margin of safety. Dr. Xie JH and colleagues at the joint study lead by the Guangzhou University of Chinese Medicine, Guangzhou said, "Long-term treatment of RRF exhibited estrogenic properties, and retarded certain age-associated degenerations" and "RRF might have the potential for further development as a safe and effective alternative/complementary to conventional medication in relieving perimenopausal symptoms."(4).

On Chinese medicinal plant Radix astragali(RA) alone in the study of 24 ovariectomized female Sprague-Dawley (SD) rats, oral application of RA significantly improved the immune functions of the ovariectomized female rats, but cannot induced the change the sex hormones levels as significantly as estrogen(5).

Dang Qui (Angelica sinensis) is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. Use conjunction with Radix Astragali and Folium Epimedii in formula RRF improved the aging degeneration of perimenopausal symptoms in animal study(2).

Folium Epimedii, deciduous or evergreen hardy perennials, native to Asia, and a few in the Mediterranean region has been used in Chinese medicine for induced sexual activity. When used together with Dang qui and Huang qi in formula RRF has shown effectively in enhanced the balancing of diminished hormones due to aging in reduced the expression of perimenopausal symptoms(3).

In take of phytoestrogen with function as weak estrogens, antioxidants, and anti-inflammatory agents(6plant based lignans, a chemical compoud found in flax seed, may be effective in ameliorated symptoms of peri menopause, according to the joint study lead University of Zurich(7),

The combination of formula RRF and Flax Seed  smoothie may hold a key in further studies in production of an effective natural ingredients for reduced the symptoms displacement and treatment of perimenopause without inducing adverse effects.

Women who are in the perimenopause stage should drink as much as they can, depending to the digestive toleration.



References
(1) Evaluation of safety of Modified-Danggui Buxue Tang in rodents: Immunological, toxicity and hormonal aspects by Xie JH1, Chen ZW2, Pan YW3, Luo DM3, Su ZR4, Chen HM1, Qin Z5, Huang SQ6, Lei G7.(PubMed)
(2) Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii: An In Vivo Study on Natural Aging Rat Model by Su JY1, Xie QF2, Liu WJ1, Lai P1, Liu DD1, Tang LH1, Dong TT3, Su ZR4, Tsim KW3, Lai XP4, Li KY5.(PubMed)
(3) Effect of a derived herbal recipe from an ancient Chinese formula, Danggui Buxue Tang, on ovariectomized rats by Xie QF1, Xie JH, Dong TT, Su JY, Cai DK, Chen JP, Liu LF, Li YC, Lai XP, Tsim KW, Su ZR.(PubMed)
(4) Evaluation of safety of Modified-Danggui Buxue Tang in rodents: Immunological, toxicity and hormonal aspects by Xie JH1, Chen ZW2, Pan YW3, Luo DM3, Su ZR4, Chen HM1, Qin Z5, Huang SQ6, Lei G7.(PubMed)
(5) Effects of a Chinese medicinal plant Radix astragali on the ovariectomized female rats by Zheng Y1, Jin Y, Zhu HB, Xu ST, Xia YX, Huang Y.(PubMed)
(6) Urinary phytoestrogen levels and frailty in older American women of the National Health and Nutrition Examination Survey (NHANES) 1999-2002: a cross-sectional study by Eichholzer M1, Richard A, Walser-Domjan E, Linseisen J, Rohrmann S.(PubMed)
(7)  Urinary phytoestrogens and depression in perimenopausal US women: NHANES 2005-2008. by Richard A1, Rohrmann S2, Mohler-Kuo M3, Rodgers S4, Moffat R5, Güth U6, Eichholzer M2.(PubMed)

The #CurableSmoothie of Carrot and Sweet Potato and Low Fat Cow Milk for Prevention of Giving Birth to Low birth-weight baby

Kyle J. Norton(Scholar, master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Low birth-weight babies
Yield: 2 serving (about 8 ounce each)
1 cup sweet potato
1/2  cup carrot
1 cup of low fat cow milk


1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of low birth-weight babies has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Low birth weight is a condition of a baby who was born below the weight of gestational age due to several reasons, including, the baby was born too soon, were small for gestational age, the poor health of the mother, nutritional deficiency, certain diseases, etc. According to the statistic of the
World health organization, globally, more than 20 million infants were born with low birth weight.

Prevalence of vitamin A E, and D deficiencies is found to associated to pre-eclampsia and lower birth-weight babies in a total of 607 VLBW and 300 term neonates(1).
Vitamin A, a fat soluble vitamin and found abundantly in carrot, is a bi-polar molecule formed by bonds between carbon and hydrogen.
Dr. Murguía-Peniche T, professor at the National Center for Child and Adolescent Health (CeASIA), said, Preterm and low birth weight infants have low levels of these nutrients and are at risk for developing detrimental health consequences associated with vitamin A and vitamin D deficiencies"(2).
The Haukeland University Hospital study suggested, In HIV-infected women, vitamin A supplementation enhanced birth weight and growth in infants. Overdosing should be avoided(3).

Vitamin E, found abundantly in sweet potato, best known for its powerful antioxidant property is a fat soluble vitamin and can be stored in our body. Pregnant women with vitamin E is connected to ivinggbirth of very low birth-weight babies(1),Dr, Shah RS and researchers at the M.S. University,said, "maternal vitamin E deficiency is one of the features associated with prematurity and intra-uterine growth retardation"(4).

Vitamin D, found in very few food but added to milk in 103-105 (IU) per cup is associated to reduced risk of giving birth of low birth-weight babies(1). 
According to the Iran University of Medical Sciences, maternal Vitamin D deficiency may increase the risk of low birth weight neonate, improving maternal vitamin D level could be beneficial on pregnancy outcome(5). In support of the above, St George Hospital, Gray Street, suggested, maternal vitamin D deficiency increased the risk of neonatal vitamin D deficiency and lower birth weight and is common among pregnant women; immigrant, veiled and dark skinned women(6).

The smoothie of Carrot and Sweet Potato and Low Fat Cow Milk may hold a key for further studies in production of effective natural ingredients for prevention of giving birth to low birth-weight babies without inducing adverse effects.
Women who are pregnant with vitamin A, E and D deficiency or due to family history, ... should drink at least one cup daily, depending to the digestive toleration.

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References
(1) VitaminA, E, and D deficiencies in tunisian very low birth weight neonates: prevalence and risk factors by Fares S1, Sethom MM1, Khouaja-Mokrani C2, Jabnoun S2, Feki M3, Kaabachi N1.(PubMed)
(2) Vitamin D, vitamin A, maternal-perinatal considerations: old concepts, new insights, new questions by Murguía-Peniche T1.(PubMed)
(3) Influence of mineral and vitamin supplements on pregnancy outcome by Hovdenak N1, Haram K.(PubMed))
(4) Vitamin E status of the newborn in relation to gestational age, birth weight and maternal vitamin E status. by Shah RS1, Rajalakshmi R, Bhatt RV, Hazra MN, Patel BC, Swamy NB, Patel TV.(PubMed)) Vitamin A status of the newborn in relation to gestational age, body weight, and maternal nutritional status.
Shah RS, Rajalakshmi R.(5) The Relationship between Maternal Vitamin D Deficiency and Low Birth Weight Neonates by Khalessi N1, Kalani M2, Araghi M1, Farahani Z3.(PubMed)