Socrates Said," Let foods be your medicine and let medicine be your foods". Let us all practice the values of the past wisdom to build a letter living and living health while we enjoy the delicious drinks

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Saturday, January 30, 2016

The Best Smoothie of Green Tea and Grape for reduced Risk and Treatment of influenza

Kyle J. Norton(Scholar, master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of influenza virus
Yield: 2 servings (about 8 ounces each)
1 1/2 cups grapes
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of influenza virus has encountered many obstacles, many ingredients showed initially promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Scientists in some well known institutions may have found the therapeutic and potential ingredients from natural sources(Green tea and grape) for reduced risk and treatment of influenza.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world.In animal model, polyphenolic compounds present in green tea, particularly catechins, are well known to process a strong anti-influenza activity in in a dose-dependent effect, especially in the early phase of lungs infection(1).

According to the Yonsei University, Catechin derivatives found in green tea also exhibited a broad spectrum activity against various subtypes of influenza viruses, through its antioxidant effect in inhibition of circulating human influenza viruses (A/H1N1, A/H3N2 and B type), H2N2 and H9N2 avian influenza virus, the viruses on red blood cell (RBC)(2).
Dr. Song JM and colleagues at the Yonsei University, polyphenolic compound catechins ((-)-epigallocatechin gallate (EGCG), (-)-epicatechin gallate (ECG) and (-)-epigallocatechin (EGC)) all showed to exhibited antiviral effect on influenza virus through altering the physical properties of viral membrane(3).

Grape is a woody vines of the genus Vitis, belong to the family Vitaceae, native to southern Turkey.
Its antioxidant, resveratrol has shown to process strong anti influenza virus, including, inhibitory effect on the NA activity of the influenza virus strain A/PR/8/34 (H1N1)(4)(5), epidemiological studies suggest.

Resveratrol (RV) in the Univ. of Rome Sapienza study also exhibits anti-inflammatory, and anti-proliferative properties against a wide variety of viruses including members of the Herpesviridae family, retroviruses, influenza A virus and polyomavirus by altering certain cellular pathways(6).

Dr. Thapa M and colleagues at the Kansas State University said, " polyphenols, such as resveratrol and epigallocatechin gallate (EGCG), showed significant anti-influenza activity in vitro and/or in vivo", especially against influenza virus (porcine H1N1 strain)(7).

Taking altogether people who are at increased risk of influenza due to weaken immunity and aging .....should drink at least one serving daily and people with influenza should drink the smoothie at 4 servings a day, depending to digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


References
(1) Anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens by Lee HJ1, Lee YN, Youn HN, Lee DH, Kwak JH, Seong BL, Lee JB, Park SY, Choi IS, Song CS.(PubMed)
(2) Biological evaluation of anti-influenza viral activity of semi-synthetic catechin derivatives by Song JM1, Park KD, Lee KH, Byun YH, Park JH, Kim SH, Kim JH, Seong BL.(PubMed)
(3) Antiviral effect of catechins in green tea on influenza virus by Song JM1, Lee KH, Seong BL.(PubMed)
(4) In vitro antiviral effects and 3D QSAR study of resveratrol derivatives as potent inhibitors of influenza H1N1 neuraminidase by Li C1, Fang JS, Lian WW, Pang XC, Liu AL, Du GH.(PubMed)
(5) [Active neuraminidase constituents of Polygonum cuspidatum against influenza A(H1N1) influenza virus].[Article in Chinese] by Chen KT1, Zhou WL, Liu JW, Zu M, He ZN, Du GH, Chen WW, Liu AL.(PubMed)
(6) Resveratrol inhibits Epstein Barr Virus lytic cycle in Burkitt's lymphoma cells by affecting multiple molecular targets by De Leo A1, Arena G, Lacanna E, Oliviero G, Colavita F, Mattia E.(PubMed)
(7) Synthesis and antiviral activity of substituted quercetins by Thapa M1, Kim Y, Desper J, Chang KO, Hua DH.(PubMed)

The Smoothie of Wolfberry, Tomato and Green Tea for Prevention of the Early Onset and Treatment of Photo Aging

Kyle J. Norton (Scholar, and Master of nutrients) All right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Imaging of long term intake of delicious smoothies loved by many with the power of reduced risk and treatment of chronic illness with no one mentions about. Epidemiological studies with strong evidences suggested that blueberry oral administration hold a potential with therapeutic values for reduced risk of women who carry the mutation gene and treatment of breast cancer(*).

The curable smoothies are collection of recipes produced from natural sources, including organic fruits and vegetables, and some herbs which have been proven effectively for reduced risk and treatment for diseases and syndromes by scientific research of clinical trials and/or studies.

The finding of foods from natural sources has been a dream of scientists and scholars since ancient time. Socrates Said," Let foods be your medicine and let medicine be your foods". Let all of us all exercise the values of the past wisdom to build a letter living and living health while enjoining these delicious drinks.

The smoothie for Prevention and Treatment of Photo Aging

Yield: 2 serving (about 8 ounce each)
1/2 cup wolfberry
1 cup tomato
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Photoaging is the premature aging of the skin due to chronic exposure of skin to ultraviolet (UV) light of the Sun.

Wolfberry, the common name for the fruit of two very closely related species, the genus of Lycium, belong to family Solanaceae, native to southeastern Europe and Asia showd to attenuate biological effects of skin photo-damage through reduction of cell apoptosis in the epidermis of skin organ cultures and pro-inflammatory cytokine(1).
Zeaxanthin is a xanthophyll, an oxygenated carotenoid found in wolfberry expressed antioxidant and blue light-absorbing properties in reduced the risk of photo damage caused by chronic exposure(2).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world.
Green tea polyphenols, according to the study by the University of Minnesota conferred protective effects on the skin against ultraviolet (UV) irradiation-induced acceleration of skin aging and reduced the degradation of fibrillar collagen and elastic fibers(3).In fact, the University of Alabama at Birmingham study also demonstrated the skin photo aging protective effect of green tea polyphenols (GTP) against ultraviolet (UV)-B through mediators of UVB-induced immune suppression and skin cancer induction(5).

Dr. Katiyar SK said," Topical application of GTP and EGCG prior to exposure of UVB protects against UVB-induced local as well as systemic immune suppression in laboratory animals, which was associated with the inhibition of UVB-induced infiltration of inflammatory leukocytes"(4).

Measurement of the lycopene concentration has shown to correlate to the structures of the furrows and wrinkles, skin roughness of 20 volunteers aged between 40 and 50 years(8).

Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house. The vegetable may be another candidate with pharmaceutical value with promising result for treatment of photo aging due to high levels of carotenoids(6).

According to the University of Hohenheim, combined supplementation of beta-carotene, alpha-tocopherol and ascorbic acid in addition to topical sunscreens may help to lower the risk of sunburning, through suppression of the early phase of UV-induced erythema cause of subsequent chronic skin damage(7).

As these result, people who are at increased risk of photo aging due to chronic exposure of ultraviolet sun light, and people already have photo skin aging should drink the juice as much as they can, depending to the toleration of digestive system.

Made From Fresh Fruits And Vegetable Recipes
Secret To A Vibrant And Healthy Lifestyle
That You Can Find Easily At The Comfort Of Your Kitchen.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

References
(1) Photo-damage protective effect of two facial products, containing a unique complex of Dead Sea minerals and Himalayan actives by Wineman E1, Portugal-Cohen M, Soroka Y, Cohen D, Schlippe G, Voss W, Brenner S, Milner Y, Hai N, Ma'or Z.(PubMed)
(2) Biomolecular and Clinical Aspects of Chinese Wolfberry by Peter Bucheli, Qiutao Gao, Robert Redgwell, Karine Vidal, Junkuan Wang, and Weiguo Zhang(PubMed)
(3) Molecular Mechanisms of Green Tea Polyphenols with Protective Effects against Skin Photoaging by Roh E1, Kim JE, Kwon JY, Park JS, Bode AM, Dong Z, Lee KW.(PubMed)
(4) Skin photoprotection by green tea: antioxidant and immunomodulatory effects by Katiyar SK1.(PubMed)
(5) Green tea polyphenols: DNA photodamage and photoimmunology by Katiyar SK1, Bergamo BM, Vyalil PK, Elmets CA.(PubMed)
(6) Immediate effects of UV radiation on the skin: modification by an antioxidant complex containing carotenoids by Césarini JP1, Michel L, Maurette JM, Adhoute H, Béjot M.(PubMed)
(7) Photoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins by Greul AK1, Grundmann JU, Heinrich F, Pfitzner I, Bernhardt J, Ambach A, Biesalski HK, Gollnick H.(PubMed)

Friday, January 29, 2016

The Delicious and Best Smoothie of Pineapple, Orange and Banana for Reduced risk and treatment of Fibromyalgia

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced risk and Treatment of Fibromyalgia
Yield: 2 serving (about 8 ounce each)
1/2 cups pineapple
1/2 cup orange

1/2 cup banana
1 cup of rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of fibromyalgia is considered as a dream of many scientist to replace the long term usage adverse effect of conventional medicine to other organs in the body.
Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Recent studies suggested that scientist in some research centers have found the naturally potential ingredients, such as pineapple(3), orange(3) and banana(3) for reduced risk and treatment for fibromyalgia.

According to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

Melatonin intake can improve sleep quality, pain and pain threshold. According to the study by the Universidade Federal do Rio Grande do Sul (UFRGS) in comparison with amitriptyline suggested that melatonin reduced significantly pain on pain score on the Visual Analog Scale compared with amitriptyline alone, through increased the inhibitory endogenous pain-modulating system(1)

In a clinical crossover study of 30 healthy volunteers consumed selected fruits one at a time, with a 1 week wash-out period between fruits, until completing all six fruits showed that consumption of some tropical fruits have significant effects on melatonin production(2).

According to the Ubon Ratchathani University, intake of pineapple, orange, or banana in health subjects experiment showed to increase the serum melatonin concentrations as well as raising the antioxidant capacity in proportion to serum melatonin levels(3).

Pineapple is a species of Ananas Comos. belong to the family Bromeliaceae and native to southern Brazil and Paraguay. Today it is widely cultivated for commercial and its rich of vitamins and mineral and digesting enzyme bromelin which seems to help digestion at the end of a high protein meal. It is second only to banana as America's most favourite tropical fruit

Dr. Johns NP and colleagues at the Khon Kaen University said," selected fruits(pineapple, orange and banana) consumption may reduce age-related melatonin reduction problems such as sleeplessness and illnesses involving oxidative damage"(4).

Orange, a species of Citrus Sinensis, belongings to the family Rutaceae and native to the Southeast Asia is round citrus fruits with finely-textured skins, orange in color and one of most popular fruits in the world.

The increased levels of melatonin content during alcoholic fermentation of orange juice may hold a key to attenuate the melatonin due to ageing(5).

Dr. Huang X and Dr. Mazza G. said," orange had the highest melatonin content" in the the direct analysis of initial methanol extracts was compared with further ethyl acetate extraction(6).

Taking altogether, intake of combination of pineapple, orange and banana induced the production of melatonin for improvement of the sleep pattern and ameliorated significantly pain on pain score may be beneficiary for treatment of symptoms of fibromyalgia.
People who are at higher risk of fibromyalgia due to aging may drink one or 2 servings a day, and people with
Fibromyalgia should drink as much as they can depending to the digestive alternation.





All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


References
(1) Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system infibromyalgia: a phase II, randomized, double-dummy, controlled trial BY de Zanette SA, Vercelino R, Laste G, Rozisky JR, Schwertner A, Machado CB, Xavier F, de Souza IC, Deitos A, Torres IL, Caumo W1.(PubMed)

(2) Use of complementary and alternative medical therapies by patients referred to a fibromyalgia treatment program at a tertiary care center by Wahner-Roedler DL1, Elkin PL, Vincent A, Thompson JM, Oh TH, Loehrer LL, Mandrekar JN, Bauer BA(PubMed)
(3) Serum melatonin levels and antioxidant capacities after consumption of pineapple, orange, or banana by healthy male volunteers by Sae-Teaw M1, Johns J, Johns NP, Subongkot S.(PubMed)
(4) Dietary intake of melatonin from tropical fruit altered urinary excretion of 6-sulfatoxymelatonin in healthy volunteers by Johns NP1, Johns J, Porasuphatana S, Plaimee P, Sae-Teaw M.(PubMed)
(5) Alcoholic fermentation induces melatonin synthesis in orange juice by Fernández-Pachón MS1, Medina S, Herrero-Martín G, Cerrillo I, Berná G, Escudero-López B, Ferreres F, Martín F, García-Parrilla MC, Gil-Izquierdo A.(PubMed)
(6) Simultaneous analysis of serotonin, melatonin, piceid and resveratrol in fruits using liquid chromatography tandem mass spectrometry by Huang X1, Mazza G.(PubMed)

Thursday, January 28, 2016

The Delicious Smoothie of Cranberry, Raspberry and Green Tea for Prevention and Treatment of Common Cold back by Renowned Institutions

Kyle J. Norton(Scholar, Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Common Cold

Yield: 2 servings (about 8 ounces each)
3/4 cup cranberry
3/4 cup raspberry
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately


The finding the natural ingredient for prevention and treatment of Common Cold to replace the medication from conventional has been facing many obstacles. Many initially potentially therapeutic values working in animal studies does not produce the same effectiveness in human trials.

Recent studies suggested that cranberry(1) and raspberry(6) and green tea(8) may have a potential effect on treatment of patient with Common Cold. Even celebrity Oprah, also found interest of using the cold-fighting concoction of freshly crushed cranberries juice(4).

Common cold is a condition of viral infection of the upper respiratory system of that lead to symptoms of runny nose, nasal congestion, sneezing, sore throat, cough, headache, etc.
According to the statistic conducted by the University of Aberdeen, cranberry, one of most comon use of herb in complementary and alternative medicine (CAM) amongst the general population.for treatment of common cold and enhanced immunity(1).

Dr. Bennett J and Dr. Brown CM. said, "Almong 40% of patients used herbal remedies, cranberry.... is one the most use to treat or prevent a health condition (e.g., common cold)(3)" in the study by the Methodist Hospital, Omaha.

Cranberry, a species of Vaccinium oxycoccos, belongings to the family Ericaceae, found in the cooler part of Northern America. Daily consumption of a cranberry beverage exhibited immune modulating effect by inducing the cells first line of defense in the epithelium, for decreased risk of common cold and flu(2), the study by the University of Florida insisted.
High molecular weight non-dialyzable material (NDM) found in Cranberry juice, may consist a therapeutic potential against both A and B influenza virus infections as the juice exhibited anti viral effects through attenuate the invasion of influenzavirus (IV) as well as to neutralize the cytotoxicity of IV in cell cultures(5).

Raspberries, used as a herbal remedy in common cold, fever and flu-like infections(6), are perennial, the edible fruit of a multitude of plant species in the genus Rubus belongings to the family Rosaceae, originated from Europe. Because of their commercial values and health benefits, the fruits have been grown for processing of quick frozen (IQF) fruit, purée, juice, or as dried fruit used in a variety of grocery products.

According to the Medical University of Gdańs, with a rich sources of phytochmicals, sanguiin H-6 and ellagic acid, raspberries process a valuable and biological properties including antioxidative, antimicrobial and cytotoxic, including treament of common cold(6).
Its ethanol-water extracts with sanguiin H-6 and ellagic acid found effectively against in actively against eight and nine bacterial strains(7), through enhancing the immune system by regulating NADPH oxidase activity against bacteria(8).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world.
L-Theanin, antioxidant found in green tea, has been found epidemiologically to consist various positive effects particular for treatment of common cold(9). According to Dr. Bukowski JF and Dr. Percival SS. the antioxidant also enhance the function of gammadeltaT cells against the proliferate to a wide variety of microbes and tumor cells, as well as decreasing the incidence of cold and flu symptoms(10).

Taking altogether people who are at increased risk of Common cold due to weaken immune system or aging .....should drink at least one serving daily and people with common cold should drink the smoothie as much as they can, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


References
(1) Complementary and alternative medicine use by otolaryngology patients: a paradigm for practitioners in all surgical specialties by Shakeel M1, Trinidade A, Ah-See KW.(PubMed)
(2) Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study by Nantz MP, Rowe CA, Muller C, Creasy R, Colee J, Khoo C, Percival SS1.(PubMed)
(3) Use of herbal remedies by patients in a health maintenance organization by Bennett J1, Brown CM.(PubMed)
(4) Oprah and Friends Share Their Favorite Cold Remedies(Oprah)
(5) High molecular weight constituents of cranberry interfere with influenza virus neuraminidase activity in vitro by Oiknine-Djian E1, Houri-Haddad Y, Weiss EI, Ofek I, Greenbaum E, Hartshorn K, Zakay-Rones Z.(PubMed)
(6) Chemical composition and biological activity of Rubus idaeus shoots--a traditional herbal remedy of Eastern Europe by Krauze-Baranowska M1, Głód D, Kula M, Majdan M, Hałasa R, Matkowski A, Kozłowska W, Kawiak A.(PubMed)
(7) Chemical composition and biological activity of Rubus idaeus shoots--a traditional herbal remedy of Eastern Europe by Krauze-Baranowska M1, Głód D, Kula M, Majdan M, Hałasa R, Matkowski A, Kozłowska W, Kawiak A.(PubMed)
(8) Effects of raspberry fruit extracts and ellagic acid on respiratory burst in murine macrophages by Raudone L1, Bobinaite R, Janulis V, Viskelis P, Trumbeckaite S.(PubMed)
(9) L-Theanin, Unique Aminoacid of Tea, and Its Metabolism, Health Effects, Safety by Türközü D1, Şanlier N.(PubMed)
(10) L-theanine intervention enhances human gammadeltaT lymphocyte function by Bukowski JF1, Percival SS.(PubMed)

Wednesday, January 27, 2016

The Never Forgotten The Curable Smoothie of Papaya for Reduced Severity of Symptoms and Treatment of Anemia (β-thalassemia and sickle cell disease)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced risk and treatment of Anemia (β-thalassemia and sickle cell disease)
Yield: 2 serving (about 8 ounce each)
1 1/2 cups papaya
1 cup of rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of anemia is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Most people understand that anemia is caused by iron deficiency in the bloodstream, but in reality anemia is characterized by deficiency in the hemoglobin of the red blood cells diminishing the ability of the blood to transport oxygen to our cells and to remove carbon dioxide.

Antioxidant plays an important role in the influences of the pharmacologic induction of fetal hemoglobin (HbF) for treatment of β-thalassemia and sickle cell disease through expression in the fetal liver, spleen and bone marrow(1).

Recent studies suggested that chronic consumption of the papaya(2) may be beneficiary to reduce symptoms and treatment for patients with anemia such as β-thalassemia and sickle cell disease.

Papaya is a species of Carica Papaya, belongs to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries. Vitamin C found abundantly in papaya out of all fruits, according to the Chinese Academy of Medical Science, improved the levels of hemoglobin-based oxygen carriers (HBOCs) through the indication of the oxygen binding curves and the molecular weights(2).

In patients with sickle cell hemoglobin from both parents and are associated with unusually large numbers of immature blood cells, C. papaya seed oil significantly increased HbSSM and HbSSF human sickle cell blood peroxidase activity and hemoglobin concentration significantly, through exhibited particular antisickling properties and reduced oxidative stress in sickle cell patient(3).

Also in patients with beta-thalassemia major and intermedia and E-beta-thalassemia due to defects and mutations in the beta-globin gene, fermented papaya preparation (FPP) improve the status of anemia through increased the content of reduced glutathione (GSH) in red blood cells (RBC), and decreased free radicals generation, membrane lipid peroxidation, and externalization of phosphatidylserine (PS) in beta-thal, major and intermedia, (in Israel) and E-beta-thal patients(4).Dr. Olalla-Saad ST said, "... reduction of oxidative status in red blood cells of patients with β- and E-β-thalassemia (β-thal) treated with fermented papaya preparation"(5) of that reducing the severity of the symptoms of anemia(6).

In fact, on sickle cell trait (HbAS) and sickle cell disease (HbSS) blood samples, long term consumption of tropical fruit extract, Carica papaya produced significant less numbers of sickle cells, the Covenant University study suggested(7).

People who are at increased risk of anemia (β-thalassemia and sickle cell disease) due to family history, genetic mutation .....should drink at least 2 serving daily and people with chronic anemia (β-thalassemia and sickle cell disease) should drink the juices as much as they can, depending to digestive toleration.
Change of life style and diet pattern are also recommended.



All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway by Macari ER1, Lowrey CH.(PubMed)
(2) Antioxidant effects of vitamin C on hemoglobin-based oxygen carriers derived from human cord blood by Chen G1, Duan Y1, Liu J1, Wang H1, Yang C1,2.(PubMed)
(3) Solenostemon monostachyus, Ipomoea involucrata and Carica papaya seed oil versus Glutathione, or Vernonia amygdalina: methanolic extracts of novel plants for the management of sickle cell anemia disease by Afolabi IS1, Osikoya IO, Fajimi OD, Usoro PI, Ogunleye DO, Bisi-Adeniyi T, Adeyemi AO, Adekeye BT.(PubMed)
(4) Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation.
Fibach E1, Tan ES, Jamuar S, Ng I, Amer J, Rachmilewitz EA.(PubMed)
(5) Fermented papaya preparation for β-thalassemia? by Olalla-Saad ST1.(PubMed)
(6) Fermented papaya preparation as redox regulator in blood cells of beta-thalassemic mice and patients by Amer J1, Goldfarb A, Rachmilewitz EA, Fibach E.(PubMed)
(7) Preliminary in vitro antisickilng properties of crude juice extracts of Persia Americana, Citrus sinensis, Carica papaya and Ciklavit® by Iweala EE1, Uhegbu FO, Ogu GN.(PubMed)

Tuesday, January 26, 2016

The Delicious Spinach and Molasses for Prevention and treatment of Iron Deficiency Anemia

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced risk and treatment of  Iron Deficiency Anemia 
Yield: 2 servings (about 8 ounces each)
1/2 cups spinach
1 cup black strap molasses
1 cup of rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of iron deficiency anemia is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Most people understand that anemia is caused by iron deficiency in the bloodstream, but in reality anemia is characterized by deficiency in the hemoglobin of the red blood cells diminishing the ability of the blood to transport oxygen to our cells and to remove carbon dioxide.
Recent studies suggested that chronic consumption of the combination of spinach(1) may be beneficiary to reduced symptoms for patients with iron deficiency anemia.

Spinach is an edible flowering plant in the genus Spinacia, belongs to the family of Amaranthaceae and native to central and southwestern Asia. It is considered as a healthy plant containing vary vitamins and minerals. According to the Department of Food Science, Food Science Building,heme iron found abundantly in spinach is recognized as a highly bioavailable source of iron suitable for treatment of iron deficiency anemia(1).

In the comparison of total iron from meat, spinach (Spinacea oleracea L.) and meat-spinach in anemia and non anemia rats, suggested that the iron absorption average is lower in spinach consumption in the severely anaemic, mildly anaemic and non-anaemic rats(2).
The comparison study conduced by Utah State University said,"between food and FeSO4 iron due to coprophagy may be explained based on two gastrointestinal nonheme iron pools, complexed and highly soluble"(3).

Molasses is the juice is boiled to concentration which promotes the crystallization of the sugar, made by extracting from the canes, usually by crushing or mashing, after the sugar cane plant is harvested and stripped of its leaves. The concentration of this first boiling and of the sugar crystals is first molasses, which has the highest sugar content.

In the comparison of the absorption of iron from grape molasses (GM) and ferrous sulfate (FS) by the Technical University showed that grape molasses is an effective iron source as ferrous sulfate (FS) in preventing iron deficiency anemia in infancy(4).

Dr. Tunuguntla A, and Dr. Sullivan MJ. said," Black strap molasses for the treatment of inflammatory bowel disease-associated anemia"(5).

The finding of the effectiveness of Smoothie of Spinach and Molasses may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of Iron Deficiency Anemia.

People who are at high risk of Iron Deficiency Anemia such as genetic mutation genes,.....should drink at least one cup daily and people with Iron Deficiency Anemia should drink the juices as much as they can depending to digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Synthesis and bioaccessibility of Fe-pheophytin derivatives from crude spinach extract by Nelson RE1, Ferruzzi MG.(PubMed)
(2) Bioavailability of total iron from meat, spinach (Spinacea oleracea L.) and meat-spinach mixtures by anaemic and non-anaemic rats by Zhang D1, Hendricks DG, Mahoney AW.(PubMed)
(3) Effect of coprophagy on bioavailability of iron from plant foods fed to anemic rats by Zhang D1, Hendricks DG, Mahoney AW.(PubMed)
(4) Absorption of iron from grape-molasses and ferrous sulfate: a comparative study in normal subjects and subjects with iron deficiency anemia by Aslan Y1, Erduran E, Mocan H, Gedik Y, Okten A, Soylu H, Değer O.(PubMed)
(5) Black strap molasses for the treatment of inflammatory bowel disease-associated anemia by Tunuguntla A, Sullivan MJ.(PubMed)

Sunday, January 24, 2016

The Tasty Smoothie of Yogurt and Honey for Reduced Risk and Treatment of Allergy

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced risk and treatment of Allergy
Yield: 2 servings (about 8 ounce each)
1 1/4 cup yogurt
1/4 cup honey
1 cup of rice milk

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of allergy is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Allergy is the over reaction of immune system to harmless substances after entering our body affecting 1 in every 3 people and is defined as the type I reactions or Immediate Hypersensitivity as a result of over production of Immunoglobulin E (IgE), a class of allergic antibody by the immune system against harmless substances of that increasingly lead to mediated release of histamine and other mediators from mast cells and basophils, resulting in allergic reaction, including mucus secretion, sneezing, itching, etc.

Recent studies suggested that the combination of yogurt(1) and honey(4) may hold an important information as a therapeutic value in reduced risk and treatment of allergy.

Yogurt, made from milk products through bacterial fermentation is considered as one of most healthy foods in balancing the bacteria in the digestive system. Dr. Brown-Riggs C said," yogurt is often a more easily digestible alternative to milk, and thus more palatable to people who experience symptoms of lactose intolerance. This was a key factor cited in the final rule to include yogurt in the Special Supplemental Nutrition Program for Women, Infants, and Children"(1).
According to the joint study lead by the Food Science Research Laboratories, R&D Division, yogurt fermented with different strains of lactobacilli and their metabolite exhibited increasing immunostimulatory exopolysaccharide (EPS) effects by keeping immune functions stable(2) against allergy.

In a randomized, double-blind, placebo-controlled trial, 44 JCPsis subjects, intake of yogurt or powder supplemented with the Bifidobacterium longum BB536 probiotic strain alleviated allergic symptoms during the pollen seasons of 2004 and 2005, through maintaining the normal function of microorganisms inhabiting the human body in health and disease(3).

The rich golden liquid is the miraculous product made by bees using nectar from flowers and considered as one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people with benefits of treating cough, fever, and inflammation in folk medicine.

In air inflammatory diseases, including asthma, aerosolised honey induced structural changes of the epithelium, mucosa, and submucosal regions of the airway that caused by the induction with ovalbumin(OVA)(4).
Manuka honey (MH) produced from the nectar of the mānuka tree at a concentration between 0.9 and 1.8 mg/mL may be safe to mucosa and efficacious treatment option for recalcitrant chronic rhinosinusitis (CRS), according to the University of Adelaide(5).

Local honey, in fact hold a important cue for reduced risk of allergy in city and local population, due to its effects in attenuated allergic reaction, such as sneezing and runny noses, according to the article of Seasonal Allergies? A Spoonful of Honey, posted in New York time on April 11-2010, the author to the editor said,"there is a simpler way for allergy sufferers to find relief: local honey. This remedy (predating Claritin and its ilk) has long been recognized around the world"(6).

Taking all together, people with high risk of allergy due to family history, weaken immune system should drink at least a serving daily to prevent the develop of seasonal allergy.
Taking foods, such as garlic, ginger, turmeric, etc.... in enhancing immunity are recommended

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


References
(1) Nutrition and Health Disparities: The Role of Dairy in Improving Minority Health Outcomes by Brown-Riggs C1.(PubMed)
(2) Enhanced natural killer cell activation by exopolysaccharides derived from yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 by Makino S1, Sato A2, Goto A2, Nakamura M2, Ogawa M2, Chiba Y2, Hemmi J2, Kano H2, Takeda K3, Okumura K4, Asami Y2.(PubMed)
(3) Influence of Bifidobacterium longum BB536 intake on faecal microbiota in individuals with Japanese cedar pollinosis during the pollen season by Odamaki T1, Xiao JZ, Iwabuchi N, Sakamoto M, Takahashi N, Kondo S, Miyaji K, Iwatsuki K, Togashi H, Enomoto T, Benno Y.(PubMed)
(4) Inhalation of honey reduces airway inflammation and histopathological changes in a rabbit model of ovalbumin-induced chronic asthma by Kamaruzaman NA, Sulaiman SA, Kaur G, Yahaya B1.(PubMed)
(5) Methylglyoxal-augmented manuka honey as a topical anti-Staphylococcus aureus biofilm agent: safety and efficacy in an in vivo model by Paramasivan S1, Drilling AJ, Jardeleza C, Jervis-Bardy J, Vreugde S, Wormald PJ.(PubMed)
(6) Seasonal Allergies? A Spoonful of Honey(NYtimes)

The Smoothie of Tomato, Carrot and Green tea for reduced risk and treatment of Endometrial Cancer

Kyle J. Norton(Scholar,Mast)er of Nutrients, All Right Reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of endometrial cancer

Yield: 2 serving (about 8 ounce each)
1 1/4 cup cooked tomato
1/4 cup carrot
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)


1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The dream of finding the natural ingredient for prevention and treatment of endometrial cancer without adverse effects in replacement of conventional medication has not been abated. Some ingredients have to discard due to it can achieve the same potent results in human trials.
Green tea(1) and carrot, tomato(4) may have a potential and therapeutic value for reduced risk and treatment of cervical cancer probably due to theirs' phytochemicals effect in ameliorated proliferation of cancer cell expression, recent studies suggested.

In a total of 995 incidence cases aged 30 - 69 from January 1997 to December 2002 and 1087 controls, Green tea consumption has shown an inverse association with endometrial cancer risk(1).
According to the First People's Hospital of Changde City study, Overall relative risk (RR) suggested that increased green tea consumption was associated with a reduced risk of endometrial Cancer, but large population-based randomized controlled trials and large prospective cohort studies are required to obtain a definitive conclusion and determine the mechanisms underlying this association(2).
Other study insisted that the inverse association of endometrial cancer risk with caffeinated coffee intake was specific to women with a body mass index 30+ kg m(3).

Tomato, a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America may have a potential use for reducing risk and treatment of endometrial cancer(4). According to the Istituto di Ricerche Farmacologiche Mario Negri, dietary carotenoids forms a favorable role of reduced risk on endometrial cancer(4). and blood serum levels of beta-carotene are inversely associated with the risk of endometrial cancer in Korean women(5).

Lycopene, another phytochemical found in tomato and carrot also exhibited anti endometrial cancer activity through inhibiting cell proliferation associated with inhibition of cell cycle progression at the G(1) phase(6).
Dr. Hirsch K and the research team at the Ben-Gurion University of the Negev and Soroka Medical Center of Kupat Holim said," carotenoids prevent several types of cancer, including mammary and endometrial cancers" and " dietary carotenoids inhibit estrogen signaling of both 17beta-estradiol and genistein, and attenuate their deleterious effect in hormone-dependent malignancies"(7).

Women who are at high risk of endometrial cancer such as genetic mutation genes,,.....should drink at least one cup daily and women with endometrial cancer should drink the juices as much as they can depending to digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


References
(1) [Green tea consumption and the risk of endometrial cancer: a population-based case-control study in urban Shanghai].[Article in Chinese] by Gao J1, Xiang YB, Xu WH, Shao CX, Ruan ZX, Cheng JR, Shu XO, Gao YT.(PubMed)
(2) Green tea, black tea consumption and risk of endometrial cancer: a systematic review and meta-analysis by Zhou Q1, Li H, Zhou JG, Ma Y, Wu T, Ma H.(PubMed)
(3) Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer by Uccella S1, Mariani A, Wang AH, Vierkant RA, Cliby WA, Robien K, Anderson KE, Cerhan JR.(PubMed)
(4) The U.S. Food and Drug Administration's evidence-based review for qualified health claims: tomatoes, lycopene, and cancer by Kavanaugh CJ1, Trumbo PR, Ellwood KC.(PubMed)
(5) Preoperative levels of plasma micronutrients are related to endometrial cancer risk by Jeong NH1, Song ES, Lee JM, Lee KB, Kim MK, Yun YM, Lee JK, Son SK, Lee JP, Kim JH, Hur SY, Kwon YI.(PubMed)
(6) Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27(Kip1) in the cyclin E-cdk2 complexes by Nahum A1, Hirsch K, Danilenko M, Watts CK, Prall OW, Levy J, Sharoni Y.(PubMed)
(7) Lycopene and other carotenoids inhibit estrogenic activity of 17beta-estradiol and genistein in cancer cells by Hirsch K1, Atzmon A, Danilenko M, Levy J, Sharoni Y.(PubMed)

Saturday, January 23, 2016

The Fabulous and Tasty Smoothie of Blueberry and Cooked Tomato for Reduced Risk and Treatment of Oxidative stress


Kyle J. Norton (Scholar, and Master of nutrients) All right reserved

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for Reduced Risk and treatment of Oxidative stress


Yield: 2 serving (about 8 ounce each)
1 cup blueberry
1/2 cup cooked tomato
1 cup rice milk

1. Place the all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately


The dream of finding the natural ingredient for prevention and treatment of oxidative stress without adverse effects in replacement of conventional medicine has not been abated. Some ingredients have to discard due to it can achieve the same potent results in human trials.
In fact, oxidative stress is considered as one of most common factor for the development of several chronic diseases, such as diabetes, cancer, cardiovascular and neurodegenerative diseases. Antioxidants, found mostly in fruits and vegetables play an important role in inhibition of the reactive oxygen species ROS through its function as a molecule that inhibits the oxidation of other molecules.

Recent studies suggested that blue berry(1), tomato(5) may consist a therapeutic value for reduced risk and treatment of oxidative stress in induction of diseases and syndromes.

Blueberry is a flower plant, belongings to the family Eriaceae and native to Northern America. The edible fruit has now been cultivated all over the world in suitable climate for commercial profits due to recent discovery of its health benefits, particular in oxidative stress effect.According to the joint study lead by the Istanbul University, Blueberries (BB) containing high antioxidant capacity, exhibited dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities in decreased the expression of oxidative stress causes of hepatic cirrhosis and preneoplastic lesions(1).

Other study in the evaluation of its antioxidants known as anthocyanins expressed the possible effect of blueberry in attenuated oxidative stress and inflammatory cytokines, through activation of immune natural killer cell count in 6 weeks of administration(2).


The joint study by China Agricultural University, in support of the effects of anthocyanins against oxidative stress suggested that the antioxidant inhibited reactive oxygen species (ROS) formation and prevented the successive events associated with the mitochondrial damage and dysfunction, including recovered activities of electron transport chain, through intervention of Acrylamide (AA) toxicity incuded by heat(3). Furthermore, daily intake of blueberry (BB) supplementations also found to decrease oxidative stress signalling, increase neurogenesis, and increase signals involved in learning and memory through increased hippocampal neurogenesis related brain function and expression of insulin-like growth factor 1 in enhanced immunity(4).

Tomato is a red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house.

In Human Mesenchymal Stem Cells, lycopene found in cooked tomato significantly increased manganese superoxide dismutase (MnSOD) expression and decreased cellular ROS levels via the PI3K-Akt pathway in regulating cell cycle(5).

Dr. Lei X and colleagues in the joint study of a total of total of 60 male C57BL/6 mice, lead by the Shanxi Medical University, indicated that lycopene exhibited anti oxidative stress through improved the neurological score and attenuated neuronal apoptosis in the BCCAO mice in activation of metabolic and anti-oxidant defenses(6).

In acute cholestasis, the phytochemical also expressed the hepato protective role in diseases related to oxidative stress through inhibition of pathogenesis of cholestasis(7).

Dr Kim M and Dr., Kim H at the Yonsei University, in the investigation of gastric carcinogenesis said:" Risk factors of gastric carcinogenesis include oxidative stress,..... " and " lycopene, one of the naturally occurring carotenoids, has unique structural and chemical features that contributes to a potent antioxidant activity(8).


Taking altogether, Smoothie of Blueberry and Cooked Tomato may be effective for reduced risk of and treatment of oxidative stress and its complications. People with high risk of oxidative stress, such as smoking,... should drink the smoothie at least one daily and people with oxidative stress induced chronic illness should drink as much as they can, depending to the digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats by Bingül İ1, Başaran-Küçükgergin C1, Aydın AF1, Soluk-Tekkeşin M2, Olgaç V2, Doğru-Abbasoğlu S1, Uysal M3.(PubMed)
(2) Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running by McAnulty LS1, Nieman DC, Dumke CL, Shooter LA, Henson DA, Utter AC, Milne G, McAnulty SR.(PubMed)
(3) The chemoprotection of a blueberry anthocyanin extract against the acrylamide-induced oxidative stress in mitochondria: unequivocal evidence in mice liver by Zhao M1, Wang P, Zhu Y, Liu X, Hu X, Chen F.(PubMed)
(4) The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing by Shukitt-Hale B1, Bielinski DF1, Lau FC1, Willis LM1, Carey AN1, Joseph JA1.(PubMed)
(5) Pretreatment with Lycopene Attenuates Oxidative Stress-Induced Apoptosis in Human Mesenchymal Stem Cells by Kim JY1, Lee JS2, Han YS3, Lee JH1, Bae I2, Yoon YM3, Kwon SM1, Lee SH4.(PubMed)
(6) Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia‑reperfusion in rats: The role of the Nrf2/HO‑1 signaling pathway by Lei X1, Lei L2, Zhang Z1, Cheng Y1.(PubMed)
(7) Hepatoprotective and antioxidant effects of lycopene in acute cholestasis by Tokaç M, Aydin S, Taner G, Özkardeş AB, Yavuz Taşlipinar M, Doğan M, Dündar HZ, Kiliç M, Başaran AA, Başaran AN.(PubMed)
(8) Anticancer Effect of Lycopene in Gastric Carcinogenesis by Kim MJ1, Kim H1.(PubMed)

Friday, January 22, 2016

The curable Smoothie of Green Tea, Grape and Orange for Reduced Risk and Treatment of Rheumatoid Arthritis(RA) back by Clinical Trials and Studies of Respectable Institutions

Kyle J. Norton(Scholar, master of nutrients), all right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Rheumatoid Arthritis
Yield: 2 serving (about 8 ounce each)
3/4 cup grape
3/4 cup orange
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place tall ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of Rheumatoid Arthritis has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders.

Green Tea Epigallocatechin-3-Gallate(1)Grape(5) and Orange(10), may be next generation of pharmaceutical ingredients for reduced risk and treatment of Rheumatoid Arthritis due to their effects in suppressing autoimmunity. According to the joint studu lead by the University of Texas Southwestern Medical Center, the polyphenol (-)-epigallocatechin-3-gallate (EGCG), EGCG significantly suppressed T cell proliferation and relative frequencies of CD4 T cells, CD8 T cells and B cell subsets through mediated the immunoregulation(1).

In rats with adjuvant-induced arthritis, green tea treatment effectively normalized the activity of glucose 6-phosphate dehydrogenase, a key enzyme of an important metabolic route (pentose monophosphate pathway) that are substantially modified by arthritis(2).

Dr. Ramadan G and colleagues in the expression of green tea used for treatment against inflammatory diseases including Rheumatoid Arthritis suggested that the potent of green tea in reduced inflammtory expression may be due to its inhibition of proinflammatory activities(3).
Furthermore, green tea extract (GTE) aslo was found effectively in regulating chemokine production and chemokine receptor expression in human RA synovial fibroblasts and rat adjuvant-induced arthritis (AIA), through expression of anti inflammatory cytokines pathways(4).

Intake of grape with abundant quercetin, resveratrol and procyanidins may be able to modulate chronic inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease,....(5).
Resveratrol is best known to consist significant anti-inflammatory effects on AA rats, which may be associated with the reduction of COX-2 and PGE2 inflammatory mediators(8)..
According to the Hyogo College of Medicine, resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells by activating caspase-9( in apoptosis and cytokine processing) and the effector caspase-3(responsible for apoptosis execution) along mitochondrial disruption(6).
Vam3, a derivative of resveratrol was found to interact with spleen tyrosine kinase (SYK) which plays a crucial role in adaptive immune receptor signalling, according to the joint study lead by the Peking Union Medical College, in extracellular antigen-induced crosslinking of type of antibody in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis(7).

Orange is a species of Citrus Sinensis, belongings to the family Rutaceae and native to the Southeast Asia. Chronic intake of citrus fruits is found to associate to lower RA risk(10)
According to the Iwaki Meisei University, Orange flavanone naringin showed effectively in inhibit the inflammatory responses in mice with collagen-induced arthritis (CIA), a mouse model for RA(9).
In collagen-induced arthritic mice, nobiletin found abundantly in orange and other citrus fruits effectively interferes with gene expression of ADAMTS-4 and -5(inflammatory regulated enzymes ), and thereby prevents cartilage destruction in CIA mice(11).

Taking altogether, people who are at increased risk of Rheumatoid Arthritis(RA) due to family history, gene mutation,....should drink at least one cup daily and people with Rheumatoid Arthritis(RA) should drink the smoothie as much as they can, depending to digestive and liver toleration.
Change life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca





References
(1) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S3, Kwon SR4, Vanarsa K3, Kim HY5, Davis LS1, Mohan C3.(PubMed)
(2) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM.(PubMed)
(3) Anti-inflammatory activity of green versus black tea aqueous extract in a rat model of human rheumatoid arthritis by Ramadan G1, El-Beih NM1, Talaat RM2, Abd El-Ghffar EA1.(PubMed)
(4) Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis by Marotte H1, Ruth JH, Campbell PL, Koch AE, Ahmed S.(PubMed)
(5) Effects of antioxidant polyphenols on TNF-alpha-related diseases by Kawaguchi K1, Matsumoto T, Kumazawa Y.(PubMed)
(6) Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner by Nakayama H1, Yaguchi T, Yoshiya S, Nishizaki T.(PubMed)
(7) A combined experimental and computational study of Vam3, a derivative of resveratrol, and Syk interaction by Jiang M1, Liu R2, Chen Y3, Zheng Q4, Fan S5, Liu P6.(PubMed)
(8) Anti-inflammatory effect of resveratrol on adjuvant arthritis rats with abnormal immunological function via the reduction of cyclooxygenase-2 and prostaglandin E2 by Chen X1, Lu J1, An M1, Ma Z1, Zong H1, Yang J1.(PubMed)
(9) Suppression of inflammatory responses after onset of collagen-induced arthritis in mice by oral administration of the Citrus flavanone naringin by Kawaguchi K1, Maruyama H, Hasunuma R, Kumazawa Y.(PubMed)
(10) Effects of antioxidant polyphenols on TNF-alpha-related diseases by Kawaguchi K1, Matsumoto T, Kumazawa Y.(PubMed)
(11) Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice by Imada K1, Lin N, Liu C, Lu A, Chen W, Yano M, Sato T, Ito A.(PubMed)

Thursday, January 21, 2016

The smoothie of Green Tea, Grape and Pumpkin for Prevention and Treatment of Polymyalgia Rheumatica(PMR) Back by Renowned Institution

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced risk and treatment of Polymyalgia Rheumatica 

Yield: 2 serving (about 8 ounce each)
1 1/4 cups grape
1/4 cup pumpkin
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for improvement of Polymyalgia Rheumatica is considered as a dream of many scientist. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center. Some even produce conflicted results in second and further studies.

Scientist at the some research centers may have found the way to reduce risk and treatment of inflammatory rheumatic disease such as Polymalagia Arthritis. Green tea(1), Grape(1) and Pumpkins(1) may be one of the findings with potential and pharmaceutical ingredients.


Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which cause pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdleas a result of the presence of a synovitis in proximal joints and periarticular structures, causing musculoskeletal symptoms in PMR.

Green tea, is a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. Its flavonoids play an important role in expression of antioxidative, anti-inflammatory and anti-neoplastic activities against chronic inflammatory diseases, including PMR through inhibiting the disorders induced by inflammatory pathways(2).

According to the Banaras Hindu University, (-)-epigallocatechin-3-gallate (EGCG), the predominant green tea polyphenol also inhibits enzyme activities and signal transduction of DNA is transferred from one bacterium to another by a virus pathways related to the inflammation and joint destruction in arthritis(3).

Resveratrol (RES), is a well-known antioxidant and anti-inflammatory compound found abundantly in grapes.

Use conjunction with Norisoboldine (NOR), the combination attenuated OC differentiation and bone erosion through the activation of AhR in bone regulation and the subsequent inhibition of NF-κB and proinlammatory pathways(4), according to the China Pharmaceutical University.Also when use together with curcumin, the combination expressed a remarkable anti-inflammatory activity with inhibition of 37-55% arthritis induction between day 16 and 22(5).
Dr. Wang P and colleagues at the Chengyang People's Hospital of Qingdao City said," Resveratrol has been shown to exert anti-inflammatory and antioxidant effects, while sodium alginate is a common pharmaceutic adjuvant with antioxidative and immunomodulatory properties" in the study of resveratrol on acute gouty arthritis(6).

Pumpkin is the genus Cucurbita and belong the family Cucurbitaceae. The origin of pumpkins is unknown, although many people believe that they have originated in North America. Its phytochemical, cucurbitacins have exhibited the anti inflammatory diseases and may also be used for reduced risk and treatment of Polymyalgia Rheumatica(PMR)(1).
According to the Cairo University, Cairo University, cucurbitacins found in Iberis amara, extract promotes anti rheumatic inflammatory conditions to help safeguard the integrity of the endothelium and reduces the risk of vascular complications(7).
The University of South of Santa Catarina study also lend a support of anti inflammatory effect of cucurbitacins through suppressing the COX-2 proinflammatory cytokines(8).
In animal model, Dr. Escandell JM and the research team at the Universitat de València said," experimental data on the chronic model, together with previously reported activity on acute and subchronic experimental models, justify the anti-inflammatory activity of cucurbitacin R and provide further evidence for the therapeutic potential of a group of natural products as anti-inflammatory agents"(9).

People who are at increased risk of Polymyalgia Rheumatica(PMR) due to aging, occupations, family history, gene mutation,....should drink at least one cup daily and people with Polymyalgia Rheumatica(PMR) should drink the smoothie as much as they can, depending to digestive and liver toleration.

Change of life style and diet pattern are also recommended.


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offerrecommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca



References
(1) Anti-inflammatory agents from plants: progress and potential by Recio MC1, Andujar I, Rios JL.(PubMed)
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)
(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM.(PubMed)

(4) Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation andInflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner by Wei ZF1, Lv Q1, Xia Y1, Yue MF1, Shi C1, Xia YF1, Chou GX2, Wang ZT2, Dai Y1.(PubMed)
(5) A novel approach to arthritis treatment based on resveratrol and curcumin co-encapsulated in lipid-core nanocapsules: In vivo studies by Coradini K1, Friedrich RB1, Fonseca FN1, Vencato MS2, Andrade DF1, Oliveira CM3, Battistel AP3, Guterres SS1, da Rocha MI2, Pohlmann AR4, Beck RC5.(PubMed)
(6) Effect of sodium alginate addition to resveratrol on acute gouty arthritis by Wang P1, Ren D, Chen Y, Jiang M, Wang R, Wang YG.(PubMed)
(7) Mechanisms Involved in the Anti-inflammatory and Vascular Effects of Iberis amara Extract by Khayyal MT1, Agha AM1, Zaki HF1, El-Sahar A1, Abdel-Aziz H2.(PubMed)
(8) Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of the cucurbitacins fraction from Wilbrandia ebracteata by Peters RR1, Baier Krepsky P, Siqueira-Junior J, da Silva Rocha JC, Marques Bezerra M, de Albuquerque Ribeiro R, de Brum-Fernandes AJ, Rocha Farias M,Castro da Rocha FA, Ribeiro-do-Valle RM.(PubMed)
(9) Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages. by Escandell JM1, Recio MC, Máñez S, Giner RM, Cerdá-Nicolás M, Ríos JL.(PubMed)

Wednesday, January 20, 2016

The Delicious Smoothie of Plum, Pomegranate Peel and Coconut milk for Reduced risk and Treatment of Osteoporosis that every 50 plus must know

Kyle J. Norton(Scholar, master of nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Osteoporosis

Yield: 2 serving (about 8 ounce each)
1 1/4 cups plums
1/4 cup Pomegranate
1 cup of coconut milk or coconut water

1. Place tall ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of osteoporosis has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Osteoporosis is condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time. maintaining the adequate levels of vitamin D and calcium was found to associate to reduced risk and development of the disease, epidemiologically.

Some research suggested that osteoporosis may also be caused by over expression of oxidative stress and deterioration of antioxidant enzymes(1) probably due to aging induced hormones deficiency.

Recent studies insisted that beside maintaining the right levels of Vitamin D and calcium, some natural sources such as plum(4), Pomegranate Peel(5) and coconut milk(8) have been found to process the pharmaceutical values for reduced risk and treatment of osteoporosis.

Plum is a genus of Prunus, containing over 15 species, relatives of the peach, nectarine and almond, belonging to family Rosaceae and native to northern Asia, Europe, North America and Africa's northwest coast, cultivated all over the globe for commercial purpose as foods and alcoholic drink.

Methanol extract from fruits of plum tree, showed potent peroxyl radical-scavenging activities and exhibited anti-osteoporosis activity through suppressing the nuclear factor-κB ligand-induced osteoclastic RAW 264.7 cells in related to bone and calcium metabolism and the pathogenesis of metabolic bone diseases(2).

According ot the Korea University, the fruits of Prunus mume also significantly stimulated the differentiation of osteoblastic MC3T3-E1 cells(an osteoblast precursor cell line ) to increase collagen synthesis or mineralization functions of osteoblasts(3).

Furthermore, According to Dr. Shen CL and colleagues at the Texas Tech University Health Sciences Center, said," dried plum have a pronounced effect on bone and chronic consumption of dried plum increased bone mass, trabecular bone volume, number, and thickness, and lower trabecular separation through enhancing bone formation and suppressing bone resorption, resulting in greater bone strength"(4).
Pomegranates is a fruit-bearing small tree, genus Punica, belongings to family Lythraceae, native to Iran but has been cultivated in Asian since ancient time.
Pomegranate peel has drawn the attention in scientist community due to its powerful antioxidants involved in some medicinal activities. In ovariectomized (OVX) C57BL/6J mice, intake of pomegranate peel extract (PGPE) could limit the process of osteopenia and significantly prevent the decrease in bone mineral density(5).
In deed, according to the study of Dr. Spilmont M and colleagues, all pomegranate parts, including Pomegranate seed oil (PSO)(7) are effective in preventing the development of bone loss probably through inhibited pro-inflammatory factors expression while stimulating anti-inflammatory ones(7) and improved oxidative status(6).

The coconut tree (Cocos nucifera) is a member of the family Arecaceae (palm family).found mostly in the coast line in the tropical region may also be beneficiary for prevention and treatment of osteoporosis(8).
Dr. Zil Hayatullina and the research team at the, in a postmenopausal osteoporosis rat model, exhibited the significantly greater bone volume and trabecular number while lowering trabecular separation, by maintaining bone structure and preventing bone loss in estrogen-deficient model(9).
The natural pure oil from coconut, according to the Payap University, also inhibited the expression of pro inflammatory cytokins and up expression of anti inflammatory and analgesic activities(10) may also reduce risk and alleviate symptoms of osteoporosis, a mild chronic inflammatory disease(11).

Taking altogether, People who are at increased risk of Osteoporosis due to family history, gene mutation,....should drink at least one serving daily and people with Osteoporosis should drink the smoothie as much as they can, depending to digestive and liver toleration.



All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca



References
(1) Time and dose-dependent effects of Labisia pumila on bone oxidative status of postmenopausal osteoporosis rat model by Effendy NM1, Shuid AN2.(PubMed)
(2) Evaluation of the antioxidant and anti-osteoporosis activities of chemical constituents of the fruits of Prunus mume by Yan XT1, Lee SH2, Li W1, Sun YN1, Yang SY1, Jang HD3, Kim YH4.(PubMed)
(3) Identification and biological evaluation of flavonoids from the fruits of Prunus mume by Yan XT1, Li W1, Sun YN1, Yang SY1, Lee SH2, Chen JB3, Jang HD4, Kim YH5.(PubMed)
(4) Fruits and dietary phytochemicals in bone protection by Shen CL1, von Bergen V, Chyu MC, Jenkins MR, Mo H, Chen CH, Kwun IS.(PubMed)
(5) Pomegranate Peel Extract Prevents Bone Loss in a Preclinical Model of Osteoporosis and Stimulates Osteoblastic Differentiation in Vitro by Spilmont M1,2,3, Léotoing L4,5, Davicco MJ6,7, Lebecque P8,9, Miot-Noirault E10, Pilet P11, Rios L12, Wittrant Y13,14, Coxam V15,16.(PubMed)
(6) Pomegranate and its derivatives can improve bone health through decreased inflammation and oxidative stress in an animal model of postmenopausal osteoporosis by Spilmont M, Léotoing L, Davicco MJ, Lebecque P, Mercier S, Miot-Noirault E, Pilet P, Rios L, Wittrant Y, Coxam V.(PubMed)
(7) Pomegranate seed oil prevents bone loss in a mice model of osteoporosis, through osteoblastic stimulation, osteoclastic inhibition and decreased inflammatory status by Spilmont M1, Léotoing L, Davicco MJ, Lebecque P, Mercier S, Miot-Noirault E, Pilet P, Rios L, Wittrant Y, Coxam V.(PubMed)
(8) Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review by Lima EB1, Sousa CN1, Meneses LN1, Ximenes NC1, Santos Júnior MA1, Vasconcelos GS1, Lima NB2, Patrocínio MC2, Macedo D1, Vasconcelos SM1.(PubMed)
(9) Virgin coconut oil supplementation prevents bone loss in osteoporosis rat model by Hayatullina Z1, Muhammad N, Mohamed N, Soelaiman IN(PubMed)
(10) Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil by Intahphuak S1, Khonsung P, Panthong A.(PubMed)
(11) Osteoporosis, inflammation and ageing by Ginaldi L1, Di Benedetto MC, De Martinis M.(PubMed)

Tuesday, January 19, 2016

The Magnificent Smoothie for Protection and Treatment against Memory and Learning Deficit

Kyle J. Norton(Scholar, Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced risk and treatment of Memory and Learning Deficit
Yield: 2 serving (about 8 ounce each)
1 1/2 cups blue berry
1/2 cup green tea drink (Make from 2 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)
1/2 cup Ginseng drink, (Make from 1 gram of dried root, soaped into a cup of hot water for 5 minutes, and set aside for cooling to room temperature)


1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for improvement of memory and learning ability is considered as a dream of many scientist. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center. Some even produce conflicted results in second and further studies.
Memory and Learning ability has been one cognitive degenerative worriness of patient with dementia, due to its progression and increased proportion with aging.
Green tea(1), Ginseng(5) and blueberry(9) may be next generation pharmaceutical agent used for enhancing the Memory and Learning ability, probably due to their phytochemicals in attenuated the cognitive dysfunction induced memory and learning loss.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Epidemiologically, green tea antioxidant such as polyphenols, is considered as protective agents in neurodegenerative diseases such as Alzheimer's disease (AD)(1).

In Learning and Memory Deficits in Ischemic Rats, the phytochemical also improved learning and memory deficits in a cerebral ischemia animal model, through inhibition of free radicals in reactive oxygen species(2).
In fact, chronic administration of green tea epigallocatechin gallate (EGCG), ameliorated learning and memory deficits in STZ-diabetic rats through attenuation of oxidative stress in dose-dependent-manner and in modulation of NO(3).
Dr. Li Q and the research team at the Peking University said," long-term green tea catechin administration prevents spatial learning and memory impairment" in animal model " by decreasing Abeta(1-42) oligomers and proteins in hippocampus "(4).

Ginseng is a slow-growing perennial plants with fleshy roots, the genus Panax, belonging to the family Araliaceae. Depending to the climate where it grows, ginseng can be classified mainly into Panax ginseng Asian ginseng (root), Red ginseng, wild ginseng, American ginseng (root).

Ginsenoside, the main constituent of ginseng, consisting the neuro protective effect, epidemiologically, showed to prevent memory loss in animal model after 8 months of administration(5), through effective of its antioxidant property.
Dr. Petkov V and , Mosharrof AH said," Standardized ginseng extract, in dose depend manner, improved learning and memory.....( as well as) greatly increased the locomotor activity of mice"(6).

According to the joint study lead by Zhejiang University, ginseng reduced the loss and injury of neurons, prevented the early onset of various neurodegenerative diseases, and attenuated impairment of hippocampus-dependent learning and memory,... through antioxidant effect of its Ginseng Rb fraction(8).

Furthermore, in basic and clinical trials, ginseng not only ameliorated on learning and memory deficits due to hippocampal lesions and aging but also enhanced the central nervous system function and hippocampal formation(7).

Blueberry is a flower plant, belong to the family Eriaceae and native to Northern America. Its flavonoid, has exhibited the significant reversal of age-related deficits on spatial memory and learning, through its interaction of signalling pathways, transcription factors and gene and/or protein expression(9).
Polyphenol-rich wild blueberry extract, in adult, male, 3-4-month-old Balb-c mice, improved learning and memory function through expression of brain antioxidant properties and inhibition of AChE activity(10).
Dr. Spencer JP at the University of Reading said," ..., a group of plant-derived compounds known as flavonoids may exert particularly powerful actions on mammalian cognition and may reverse age-related declines in memory and learning" and " possess the greatest potential to act on the cognitive processes"(11), probably due to its effect in activating signalling pathways, reducing neuroinflammation and inducing vascular effects potentially capable of causing new nerve cell growth in the hippocampus(12).

The finding of the effectiveness of Green Tea, Ginseng and Blueberry may serve as cornerstones of pharmaceutical target for further studies to establish a potential medication for treatment of Memory and Learning deficits in patient with Neuro deficit disease.

People who are at high risk of Memory and Learning deficit due to aging, genetic mutation genes such as amyloid precursor protein (APP),.....should drink at least one serving daily and people with Memory and Learning ability should drink the juices no more than 4 servings a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca





References
(1) Green tea polyphenols protect against okadaic acid-induced acute learning and memory impairments in rats by Li H1, Wu X1, Wu Q1, Gong D1, Shi M1, Guan L1, Zhang J1, Liu J1, Yuan B1, Han G2, Zou Y3.(PubMed)
(2) Green Tea Extract Ameliorates Learning and Memory Deficits in Ischemic Rats via Its Active Component Polyphenol Epigallocatechin-3-gallate by Modulation of Oxidative Stress and Neuroinflammation by Wu KJ1, Hsieh MT, Wu CR, Wood WG, Chen YF.(PubMed)
(3) Chronic epigallocatechin-3-gallate ameliorates learning and memory deficits in diabetic rats via modulation of nitric oxide and oxidative stress by Baluchnejadmojarad T1, Roghani M.(PubMed)
(4) Long-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing Abeta1-42 oligomers and upregulating synaptic plasticity-related proteins in the hippocampus by Li Q1, Zhao HF, Zhang ZF, Liu ZG, Pei XR, Wang JB, Li Y.(PubMed)
(5) Long-term ginsenoside consumption prevents memory loss in aged SAMP8 mice by decreasing oxidative stress and up-regulating the plasticity-related proteins in hippocampus by Zhao H1, Li Q, Zhang Z, Pei X, Wang J, Li Y.(PubMed)
(6) Effects of standardized ginseng extract on learning, memory and physical capabilities by Petkov VD1, Mosharrof AH.(PubMed)
(7) Proof of the mysterious efficacy of ginseng: basic and clinical trials: effects of red ginseng on learning andmemory deficits in an animal model of amnesia by Nishijo H1, Uwano T, Zhong YM, Ono T.(PubMed)
(8) Ginseng Rb fraction protects glia, neurons and cognitive function in a rat model of neurodegeneration by Xu K1, Zhang Y2, Wang Y1, Ling P2, Xie X1, Jiang C1, Zhang Z3, Lian XY1.(PubMed)
(9) Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects by Rendeiro C1, Guerreiro JD, Williams CM, Spencer JP.(PubMed)
(10) Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity by Papandreou MA1, Dimakopoulou A, Linardaki ZI, Cordopatis P, Klimis-Zacas D, Margarity M, Lamari FN.(PubMed)
(11) The impact of fruit flavonoids on memory and cognition by Spencer JP1.(PubMed)
(12) Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer's disease pathophysiology by Vauzour D1.(PubMed)