Socrates Said," Let foods be your medicine and let medicine be your foods". Let us all practice the values of the past wisdom to build a letter living and living health while we enjoy the delicious drinks

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Tuesday, May 10, 2016

All About #CurableVitamins: The effect of VitaminB2 on Endometrial Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Vitamins are organic compounds and vital nutrients needed by your body to grow and develop in a profound way.

Vitamin B2
Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc. The vitamin is essential for normal cellular growth and function and best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.


    The Effect of Vitamin B2 on Endometrial Cancer

The incidence of endometrial cancer among white women are higher in comparison of black. According to the statistic, the risk of endometrial cancer among women is 1 in 7000. Every year, about 40,000 women in US are diagnosed with the disease. Women who carry certain mutation genes, such as BRCA1 or the BRCA2 are associated to increased risk of endometrial cancer..


Epidemiological studies. linking dietary vitamin B2 in reduced risk of endometrial cancer have produced inconclusive results. The study of Harvard School of Public Health showed a inverse association of vitamin B2 related to the risk of endometrial cancer in a relatively small size of study(5). the co administration of riboflavin (45 mg/kg bw/day), niacin (100 mg/kg bw/day) and ascorbic acid (200 mg/kg bw/day) along with tamoxifen (45 mg/kg bw/day), in experimental animals with endometrial cancer bearing rats, exhibited a significant decrease in the activity of glycolytic enzymes and a significant increase in the deficient activities of gluconeogenic enzymes to near normal levels, but not individually(6). Unfortunately, the study of Fu Dan University School of Public Health indicted "no significant association was observed for dietary vitamin B1 or vitamin B2 and risk of endometrial cancer", in a population-based case-control study of 1,204 newly diagnosed endometrial cancer cases and 1,212 age frequency-matched controls(7)(8). In the study of one-carbon metabolism correlated to the incidence of endometrial cancer using 26 years of follow-up data from the Nurses' Health Study, indicated a no association of endometrial cancer risk with dietary levels of folate, choline, methionine, vitamin B2, vitamin B6 or vitamin B12(9).

Taking altogether, without going into reviews, composited administration of vitamin B2 and other micro nutrients such as niacin and ascorbic acid, but not vitamin B2 itself may be associated in reduced risk and treatment of endometrial cancer. But large example and multi-centers studies are necessary to identify their effectiveness. Over doses for a prolong period may cause symptoms of skin rashes, hypersensitivity, high blood pressure etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.

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References
(1) Conference on "Multidisciplinary approaches to nutritional problems". Symposium on "Nutrition and health". Cruciferous vegetable intake and the risk of human cancer: epidemiological evidence BY Kim MK, Park JH(PubMed)
(2) Epidemiological studies on brassica vegetables and cancer risk by Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA(PubMed)
(3) Brassica vegetables and cancer prevention. Epidemiology and mechanisms by van Poppel G, Verhoeven DT, Verhagen H, Goldbohm RA.(PubMed)
(4) Fruits and vegetables and endometrial cancer risk: a systematic literature review and meta-analysis by Bandera EV, Kushi LH, Moore DF, Gifkins DM, McCullough ML(PubMed)(5) Diet in relation to endometrial cancer risk: a case-control study in Greece by Petridou E1, Kedikoglou S, Koukoulomatis P, Dessypris N, Trichopoulos D(PubMed)
(6) Therapeutic potential of riboflavin, niacin and ascorbic acid on carbohydrate metabolizing enzymes in secondary endometrial carcinoma bearing rats by Sundravel S1, Shanthi P, Sachdanandam P.(PubMed)
(7) Nutritional factors in relation to endometrial cancer: a report from a population-based case-control study in Shanghai, China by Xu WH1, Dai Q, Xiang YB, Zhao GM, Ruan ZX, Cheng JR, Zheng W, Shu XO.(PubMed)
(8) Dietary folate intake, MTHFR genetic polymorphisms, and the risk ofendometrial cancer among Chinese women by Xu WH1, Shrubsole MJ, Xiang YB, Cai Q, Zhao GM, Ruan ZX, Cheng JR, Zheng W, Shu XO.(PubMed)

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