Socrates Said," Let foods be your medicine and let medicine be your foods". Let us all practice the values of the past wisdom to build a letter living and living health while we enjoy the delicious drinks

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Thursday, December 31, 2015

Research Attributed to Kyle J. Norton, The Curable Smoothie of Blueberry, Grape and Green tea Prevention and Treatment of Anxiety

Kyle J. Norton(Scholar, Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced risk and treatment of anxiety
Yield: 2 serving (about 8 ounce each)
1 cup organic mulberry fruit juice or Blueberry Juice
1/2 cup grape
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)


1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Anxiety is the psychocological disorder characterized by a feeling of excessive uneasiness and worriness. Blueberry(1), grape(2) and green tea(3) due to theirs antioxidants anthocyanins(1), resveratrol(2) and catechins(3) respectively, may be the next generation of therapeutic ingredients for reduced risk and treatment of anxiety.

In adult rats study, consumed approximately 3.2 mg kg(-1)day (oral), of the anthocyanins found in fruits especially in blueberry, significantly reduced the memory deficits, anxiety and improved locomotion(3).Dr. Valcheva-Kuzmanova S and, Zhelyazkova-Savova M. in the classification of aronia melanocarpa fruit juice rich with anthocyanin suggested that the juice exhibited neither an anxiolytic-like effect with no changed significantly horizontal and vertical locomotor activity, nor did it adversely affect working memory(4)

Grape, containing high amount of resveratrol, is a woody vines of the genus Vitis, belonginjgs to the family Vitaceae, native to southern Turkey. Epidemiological studies, strong evidences through the accumulated data suggested that dietary supplements rich in important phytochemicals resveratrol significantly decreases anxiety/depressive behaviours(6).
Pterostilbene, a natural analog of resveratrol, exhibited anxiolytic-like activity without effecting locomotor activity, through regulating cellular processes(7).
Dr.Sönmez U and the research team at the Dokuz Eylul University Inciralti, in the study of traumatic brain injury in immature rats said," resveratrol decreased anxiety and increased cortex/hippocampus dependent memory of animals subjected to blunt head trauma"(8).

Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.
Flavanols, a natural products found in green tea, inhibited anxiety like symptoms in adult male C57BL/6 mice, through mood-modulating effects(9).
Dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis has found to associate to depression and anxiety, chronic administration of catechin (CTN) significantly alleviated of the complex symptoms associated with depression and anxiety disorders, on chronic CORT-induced behavioral alterations using the forced swimming test (FST), according to the Acupuncture and Meridian Science Research Center(10).
Furthermore, "(-)-epigallocatethin-3-O-gallate (EGCG) (another catechins phytochemical found in green tea),... reverses caffeine-induced anxiogenic-like effects" and "exhibited anxiolytic effects in an animal model" Dr. Park KS and the research team at the Chungbuk National University said.

Taking altogether, people who are at increased risk of anxiety due to family history, gene mutation .....should drink at least one serving daily and people with chronic anxiety should drink the juices at least 3 times a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

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References
(1) Berry anthocyanins and their aglycons inhibit monoamine oxidases A and B by Dreiseitel A1, Korte G, Schreier P, Oehme A, Locher S, Domani M, Hajak G, Sand PG.(PubMed)
(2) Effect of resveratrol on behavioral performance of streptozotocin-induced diabetic mice in anxiety tests by Damián JP1, Acosta V, Da Cuña M, Ramírez I, Oddone N, Zambrana A, Bervejillo V, Benech JC.(PubMed)
(3) Caffeine consumption and self-assessed stress, anxiety, and depression in secondary school children by Richards G1, Smith A2.(PubMed)
(4) Effect of lyophilised Vaccinium berries on memory, anxiety and locomotion in adult rats by Ramirez MR1, Izquierdo I, do Carmo Bassols Raseira M, Zuanazzi JA, Barros D, Henriques AT.(PubMed)
(5) Anxiolytic-like effect of Aronia melanocarpa fruit juice in rats by Valcheva-Kuzmanova S1, Zhelyazkova-Savova M.(PubMed)
(6) Natural products, micronutrients, and nutraceuticals for the treatment of depression: A short review by Nabavi SM, Daglia M, Braidy N, Nabavi SF.(PubMed)
(7) Anxiolytic action of pterostilbene: involvement of hippocampal ERK phosphorylation by Al Rahim M1, Rimando AM, Silistreli K, El-Alfy AT.(PubMed)
(8) Neuroprotective effects of resveratrol against traumatic brain injury in immature rats by Sönmez U1, Sönmez A, Erbil G, Tekmen I, Baykara B.(PubMed)
(9) Plant-derived flavanol (-)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice by Stringer TP1, Guerrieri D1, Vivar C1, van Praag H1.(PubMed)

Wednesday, December 30, 2015

Research Attributed to Kyle J. Norton, The Curable Smoothie of Green Tea and Grape for Prevention and treatment of Alzheimer's disease


Kyle J. Norton(Scholar, Master of Nutrients) All right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and  treatment of Alzheimer's disease 

Yield: 2 serving (about 8 ounce each)
1 1/2 cups grapes of any kind with seeds
1 cup green tea drink 1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place the grapes, green tea, in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately


The findings of a natural ingredient for treatment and delay the progression of Alzheimer's disease from scientific communities have not been abating. Many ingredients showed extremely prominent in animal studies do not produce the same effects in human trials.

Alzheimer's disease is a severe aging chronic neurodegenerative disorder of the brain, causing problems of memory, thinking and behavior severe enough to affect language communication, lifelong hobbies and social life.

Alzheimer's gets worse over time, and it is fatal.

Certain phytochemicals such as Ginkgo biloba flavonoids, soybean isoflavones, theanine have exhibited neuroprotective effect against AD through inhibition on Abeta-induced neurotoxicity in cell culture and AD transgenic animal models, according to Dr. Zhao Y and Dr. Zhao B at the Harbin Institute of Technology at Weihai(2).

Recent study suggested, green tea catechins and grape skin and seed resveratrol have shown to prevent the early onset of the diseases through their anti-amyloidogenic, anti-oxidative, and anti-inflammatory properties(1) as well as exhibiting phototropic gene protective effect against the promotion of Alzheimer's disease(6)

Resveratrol (3,4',5-trihydroxystilbene) a polyphenolic compound, a naturally occurring phytochemical effectively promotes the non-amyloidogenic cleavage of the amyloid precursor protein, enhances clearance of amyloid beta-peptides, and reduces neuronal damage through its neuroprotective benefits in animal models of AD(3).

Amyloid beta (Aβ or Abeta), the peptides of 36–43 amino acids involved the the production and deposition of the amyloid-beta peptide (Abeta). Its aggregation has been strongly associated with the neurodegenerative pathology and a promotion of harmful event rated to Alzheimer's disease (AD)(5).

The Litwin-Zucker Research Center for the Study of Alzheimer's Disease and Memory Disorders, study found that people who are wine drinkers are associated with a lower incidence of Alzheimer's disease, through effects of intracellular degradation of Abeta via a mechanism that involves the proteasome in degrade unneeded or damaged proteins(4). Other researchers suggested the lower risk of red wine may be attributed to the effects of resveratrol and intracellular free-radical scavenger glutathione involved cell viability and an anti-oxidative action(7).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. The drink has showed to reduced risk neurodegenerative disorder, through its anti-oxidant phenolic compounds(9)

Dr. Bastianetto S and the research team at the McGill University said," the neuroprotective abilities of ... resveratrol, and (+)-catechin result from their antioxidant properties rather than their purported inhibitory effects on intracellular enzymes"(8).

Through its anti the antioxidant, anti-inflammatory, anti-amyloidogenic, neuroprotective, and cognitive action in reduced deposition of amyloid plaques and neurofibrillary tangles, as well as microglial and astroglial activation, green tea may be one of the potential therapeutic compounds used in delay the onset of AD or slow down its progression(10).

Similar to resveratrol (-)-epigallocatechin gallate (EGCG), a green tea polyphenol reduced Aβ aggregation, inhibits toxic oligomers, Dr. Wobst HJ and the research team lead byMax Delbrück Center for Molecular Medicine said(11).

The finding of the effectiveness of Green Tea and Grape and theirs phytochemicals may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of Alzheimer's disease.

People who are at high risk of Alzheimer's disease such as genetic mutation genes such as amyloid precursor protein (APP),.....should drink at least one cup daily and people with Alzheimer's disease should drink the juices as much as they can depending to digestive toleration.


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


References

(1) Naturally occurring phytochemicals for the prevention of Alzheimer's disease by Kim J1, Lee HJ, Lee KW.(PubMed)
(2) Natural antioxidants in prevention and management of Alzheimer's disease by Zhao Y1, Zhao B.(PubMed)
(3) Resveratrol, a neuroprotective supplement for Alzheimer's disease by Li F1, Gong Q, Dong H, Shi J.(PubMed)
(4) Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides by Marambaud P1, Zhao H, Davies P.(PubMed)
(5) Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation by Feng Y1, Wang XP, Yang SG, Wang YJ, Zhang X, Du XT, Sun XX, Zhao M, Huang L, Liu RT.(PubMed)
(6) Pleiotropic Protective Effects of Phytochemicals in Alzheimer's Disease by Sergio Davinelli, 1 Nadia Sapere, 1 Davide Zella, 2 Renata Bracale, 1 Mariano Intrieri, 1 and Giovanni Scapagnini 1(PMC)
(7) Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity by Savaskan E1, Olivieri G, Meier F, Seifritz E, Wirz-Justice A, Müller-Spahn F.(PubMed)
(8) Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons by Bastianetto S1, Zheng WH, Quirion R.(PubMed)
(9) Comparative Histological Study on the Therapeutic Effect of Green Tea and Stem Cells in Alzheimer's DiseaseComplicating Experimentally Induced Diabetes by Bassiony HS1, Zickri MB1, Metwally HG2, Elsherif HA1, Alghandour SM1, Sakr W3.(PubMed)
(10)Natural compounds and plant extracts as therapeutics against chronic inflammation in Alzheimer's disease--a translational perspective.Apetz N, Munch G, Govindaraghavan S, Gyengesi E1.(PubMed)
(11)The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios.
Wobst HJ1, Sharma A2, Diamond MI2, Wanker EE3, Bieschke J4(PubMed)

Tuesday, December 29, 2015

Research Attributed to Kyle J. Norton, The Curablesmoothie: The Blueberry Smoothie for Reduced Risk and Treatment of Breast Cancer

Kyle J. Norton(Scholar, Master of Nutrients). All right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for women with high risk and breast cancer 

Yield: 2 serving (about 8 ounce each)
1 1/2 cups Blueberries
1 cup rice milk
4-6 ice cubes

1. Place all the ingredients in a blender.
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately.

The dream of finding of a natural ingredient for replacement of serious side effects of chemotherapy for treatment of breast caner has been extremely difficult, probably due to physical differences in testing subjects.

Breast cancer (malignant breast neoplasm) is a cancer originated in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).

In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.

Blueberry, a flower plant, belong to the family Eriaceae and native to Northern America contains several essential phytochemicals and nutrients, including, lutein and zeaxanthin, zinc, potassium, phosphorus, iron, calcium and vitamins.

Blueberry or whole blueberry powder may hold a key for reduced risk breast cancer and for treatment of the diseases. Recent studies insisted that intake of the fruits and the fruit products showed to the improve the survival rate of women with breast cancer.

In estrogen-mediated breast cancer, blueberry-supplemented diet protect women against breast cancer induced by 17β-estradiol (E2)-mediated mammary tumorigenesis(breast cancer)(1) in animals received 5% blueberry diet, either 2 weeks prior to or 12 weeks study.Dr. Ravoori S and the research team at the University of Louisville suggested, the effectiveness of blue berry for treatment of breast cancer may be a result of the exhibition of its phytochemicals reducing mammary tissue proliferation and tumor burden, tumor latency(2).

In fact the intake of berries reduced significantly mammary tumor incidence (10-30%) by suppressing the levels of E(2) to prevent the early onset of E(2) breast cancer(3).
Dr. Aiyer HS and Gupta RC. said, blueberries and other berries promote anti proliferation and apoptosis of breast cancer cell is due its effects in modulating enzymes of estrogen metabolism.

In breast cancer cell lines MCF7 and MDA-MB-231, pterostilbene, a phytochemical found in blueberries, effectively suppressed tumorigenesis and metastasis of cancer stem cells (CSCs) through reduced expressions in promoted(4) and increased tumor cell proliferation of breast cancer(5).

Addition to that, the joint study lead by the Indian Institute of Technology Roorkee showed that pterostilbene not only expressed itself as a effective inducer of apoptosis in human breast in affecting various cellular targets, it also may be a chemopreventive potential based on its stronger anti-proinflammatory cytokines and anti-inflammatory activities against many forms of diseases(6).

In the study of MCF7, Hs578t and MDA-MB-231 breast cancercell lines, pterostilbene suppressed tumor growth and metastasis in MDA-MB-231, the triple-negative breast cancer and Hs578t cells through inhibition of the migratory and invasive potential by blocking the initiate the metastatic process(7).

Further more, the phytochemical also found to inhibit breast cancer regardless of estrogen receptor (ER-α36 positive or negative breast cancer)status by inducing apoptosis(8) and anti-proliferation(9), with or without the execution of cell death in apoptotic cells(8).

The finding of the effectiveness of blueberry and its phytochemical pterostilbene may serve as a cornerstone of pharmaceutical target for further studies as well as a protential medication for treatment of breast disease.

Women who are at high risk of breast cancer such as genetic mutation genes BRCA1 and BRCA2 should drink at least one cup daily and women with breast cancer should drink the juices as much as they can depending to digestive toleration.


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


References
(1) Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer by Jeyabalan J1, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC.(PubMed)
(2) Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry by Ravoori S1, Vadhanam MV, Aqil F, Gupta RC.(PubMed)
(3) Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism by Aiyer HS1, Gupta RC.(PubMed)
(4) Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit by Mak KK1, Wu AT, Lee WH, Chang TC, Chiou JF, Wang LS, Wu CH, Huang CY, Shieh YS, Chao TY, Ho CT, Yen GC, Yeh CT.(PubMed)
(5) Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression by Vesuna F1, Lisok A, Kimble B, Raman V.(PubMed)
(6) Understanding the mode of action of a pterostilbene derivative as anti-inflammatory agent by Nikhil K1, Sharan S1, Palla SR2, Sondhi SM2, Peddinti RK2, Roy P3.(PubMed)
(7) Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition by Su CM1, Lee WH2, Wu AT3, Lin YK4, Wang LS5, Wu CH6, Yeh CT7.(PubMed)
(8) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)
(9) Estrogen receptor-α36 is involved in pterostilbene-induced apoptosis and anti-proliferation in in vitro and in vivobreast cancer by Pan C1, Hu Y2, Li J3, Wang Z4, Huang J5, Zhang S1, Ding L5.(PubMed)

Monday, December 28, 2015

The Number #1 Smoothie of Cooked Tomato, Grape and Green Tea for Protection against Cognitive Dysfunction


Kyle J. Norton(Scholar, Master of Nutrient)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for people with high risk of Cognitive Dysfunction and Cognitive Dysfunction

Yield: 2 serving (about 8 ounce each)
3/4 cup cooked tomato
3/4 cup of grape
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)


1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house. Phytochemical lycopene found in the skin of the fruit has shown to protect our body against various diseases, such as prostate cancer, enlarge prostate. For the release of lycopene, tomato must be cooked.

In cognitive impairment in fructose-drinking insulin resistant rats, lycopene found in tomato is a phytochemicals in carotenoid family, exhibited anti cognitive impairment effects, through ameliorated anti-oxidative stress, anti-inflammatory reaction(1).

Dr. Prakash A and Dr. Kumar A. in the study of memory impairment and mito-oxidative damage induced by colchicine, showed that long term administration of lycopene significantly improved memory retention and attenuated mito-oxidative damage parameters, inflammatory markers of that induced cognitive function in colchicine damage animals(2).Furthermore, according to the the joint study lead by the Sorbonne Paris Cité Université, dietary rich with carotenoid and providing sufficient quantity and variety of coloured fruits and vegetables may reduce risk of early onset of aging related cognitive function(3).


Grape is a woody vines of the genus Vitis, belong to the family Vitaceae, native to southern Turkey. Recent study suggested that its antioxidant resveratrol may be the next generation natural food source used for reduced risk and treatment in patinet with cognitive dysfunction(4).Dr. Nooyens AC and the research team at the National Institute for Public Health and the Environment (RIVM) and Maastricht University said, "red wine(processed high amount of antioxidant resveratrol) was inversely associated with the decline of cognitive function", in the study of 2613 men and women of the Doetinchem Cohort Study, aged 43-70 years at baseline (1995-2002)(5). In prenatal stress-induced cognitive dysfunction animal model, oral administration of resveratrol in early and late gestational stress significantly reduced spatial learning and memory and cognitive deficit, through numbers of activity in brain homogenate(6)and against oxidative damage(7).

Green tea containing more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. according to epidemiological studies, chronic consumption of green tea is also associated to reduce risk of cognitive dysfunction due to aging.A double-blind placebo-controlled study conducted by LG Household and Health Care Co, green tea extract ant its antioxidant l-theanine exhibited cognitive alertness in cognitive impairment patients in brain theta waves expression(8).

In the cross-sectional data from a community-based Comprehensive Geriatric Assessment (CGA) conducted in 2002, high consumption of green tea was associated with a lower prevalence of cognitive impairment, the Tohoku University Graduate School of Medicine, insisted(9).
Dr Shimbo M and the research team at the Graduate School of Tokyo Medical and Dental University, said," ...., consumption of brewed green tea was not statistically associated with any decrease in risk of mental ill-health among either males or females"(10).

The finding of the effectiveness of Cooked Tomato, Grape and Green Tea for Protection against Cognitive Dysfunction, through theirs phytochemicals may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of Cognitive Impairment.

People who are at high risk of Cognitive Impairment. such as aging, genetic mutation genes,.....should drink at least one cup daily and people with Cognitive Dysfunction should drink the juices as much as they can depending to digestive toleration.


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca



Reference
(1) Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats by Yin Q1, Ma Y1, Hong Y1, Hou X1, Chen J1, Shen C2, Sun M1, Shang Y1, Dong S1, Zeng Z3, Pei JJ4, Liu X5(PubMed)
(2) Lycopene protects against memory impairment and mito-oxidative damage induced by colchicine in rats: an evidence of nitric oxide signaling by Prakash A1, Kumar A.(PubMed)
(3) Carotenoid-rich dietary patterns during midlife and subsequent cognitive function by Kesse-Guyot E1, Andreeva VA1, Ducros V2, Jeandel C3, Julia C1, Hercberg S1, Galan P1.(PubMed)
(4) Resveratrol and Alzheimer's disease: message in a bottle on red wine and cognition by Granzotto A1, Zatta P2.(PubMed)
(5) Consumption of alcoholic beverages and cognitive decline at middle age: the Doetinchem Cohort Study by Nooyens AC1, Bueno-de-Mesquita HB1, van Gelder BM1, van Boxtel MP2, Verschuren WM1(PubMed)
(6) Neuroprotective effect of resveratrol against prenatal stress induced cognitive impairment and possible involvement of Na(+), K(+)-ATPase activity by Sahu SS1, Madhyastha S, Rao GM.(PubMed)
(7) Resveratrol for prenatal-stress-induced oxidative damage in growing brain and its consequences on survival of neurons by Madhyastha S, Sahu SS, Rao G.(PubMed)
(8) A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitiveimpairment: a double-blind placebo-controlled study by Park SK1, Jung IC, Lee WK, Lee YS, Park HK, Go HJ, Kim K, Lim NK, Hong JT, Ly SY, Rho SS.(PubMed)
(9) Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya Project 1. by Kuriyama S1, Hozawa A, Ohmori K, Shimazu T, Matsui T, Ebihara S, Awata S, Nagatomi R, Arai H, Tsuji I.(PubMed)
(10) Green tea consumption in everyday life and mental health by Shimbo M1, Nakamura K, Jing Shi H, Kizuki M, Seino K, Inose T, Takano T.(PubMed)

Sunday, December 27, 2015

The Curable Smoothies: The Smoothie Recipe of Tangerine peels and Grapes For Reduced Risk and Treatment of Lung Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of lung cancer 
Yield: 2 serving (about 8 ounce each)
1 1/2 cups grapes of any kind with seeds
1 medium tangerine peels
1 cup rice milk

1. Place the grapes, tangerine peels, rice milk, in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Recent studies suggested that tangerine peels and grape skin and seeds may have a potential effect on treatment of patient with lung cancer.

Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistic.

Tangerine, one of the winter fruits found on Chinese New year represent prosperity and good fortune, now has been cultivated all over the world in suitable climate for commercial and health benefits. The peel of the fruit also has been recorded in Chinese herbal medicine over thousand of years for treatment of respiratory diseases, including cough, asthma,.........

Epidemiological study suggested that Tangeretin has long been found to consist the ability in inhibition of apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways (such as P53 antigen and caspase activation).

Tangeretin, a major phytochemicals in tangerine peels, in vitro and in vivo exhibited anti lung cancer effects through induced CL1-5 cell apoptosis and autophagy and inhibited NSCLC cell proliferation, and induce G(2)/M phase arrest and via the mitochondrial apoptotic pathway and autophagy(1)

"By interference of the cancer cell division and destruction of the function of new cell formation in mitochondrial apoptotic pathway involved the The Bcl-2 family of proteins" researcher, Norton said " The finding of tangeretin may provide us a natural sources for treatment of lung with little or no adverse effect".


In support of the finding, Dr. Charoensinphon N and the research team at the University of Massachusetts suggested, in comparison of the effects of Tangeretin (TAN) and 5-demethyltangeretin (5DT) on three human nonsmall cell lung cancer (NSCLC) cells, 5DT inhibited NSCLC cell growth by inducing G2/M cell cycle arrest and apoptosismuch stronger than the phytochemical TAN(2).
Other study also insisted that the effectiveness of the phytochemicals for treatment of lung cancer in tangerine peel may be associated to the suppression of inflammation and cell proliferation in the Nuclear factor-κB (NF-κB) family and certain signaling proteins(5).

Grape skin and seeds contains many concentrations, including vitamin E, flavonoids, linoleic acid,oligomeric proanthocyanidins(OPCs), etc..The herb has been used in traditional medicine as antioxidant, anti-inflammatory agents.

Resveratrol, an phytochemical found abundantly in grape seed and skin is a class of Stilbenoids. Epidemiologically, the antioxidant has found effectively for treatment many types of cancer(6) including prostate cancer(7).
Dr. Zhu Y and the research team at the Genomic Medicine Institute, Cleveland Clinic indicated the effects of resveratrol for treatment of non-small cell lung cancer (NSCLC) patients with activating EGFR mutations, probably through induction of cell apoptosis, autophagy, cell cycle arrest and senescence accompanied by increased expression of anti inflammation and proliferation pathways(8).

Analogue of resveratrol, (Z)3,4,5,4'-trans-tetramethoxystilbene (TMS), also inhibited gefitinb-resistant non-small cell lung cancer through inducing apoptosis and autophagy via mediation of calcium signaling pathway(9).

Other studies in support of the above include the joint study lead by the Northeast Ohio Medical University, Rootstown,showed that resveratrol inhibits lung cancer cells, through activation of GADD45α in induction of cancer cell suicide(10). Dr. Sancho M and Dr. Mach N said," The wine polyphenols plays a significant role as antioxidant and prooxidant in cancer, although more extensive studies are required to determine the clinical significance in humans"(11).

" The combination of tangerine and grape smoothie may hold a key to reduce risk for people who are at higher risk of lung cancer as well as for treatment of patient who have already developed the disease" researcher Norton said, " people with lung cancer in any stage should drink as much as they can depending to the digestive toleration"


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months




References

(1) Tangeretin Derivative, 5-Acetyloxy-6,7,8,4'-tetramethoxyflavone Induces G2/M arrest, Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer Cells In vitro and In vivo(PubMed)Li YR1, Li S2, Ho CT3, Chang YH1, Tan KT1,4, Chung TW5, Wang BY6, Chen YK7, Lin CC1.

(2) 5-demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis by Charoensinphon N1, Qiu P, Dong P, Zheng J, Ngauv P, Cao Y, Li S, Ho CT, Xiao H.(PubMed)
(3) Tangeretin, a citrus polymethoxyflavonoid, induces apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways by Dong Y1, Cao A2, Shi J3, Yin P2, Wang L2, Ji G4, Xie J4, Wu D2.(PubMed)
(4) Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells by Zhang X1, Zheng L1, Sun Y1, Wang T2, Wang B3(PubMed)
(5) Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells by Chen KH1, Weng MS, Lin JK.(PubMed)
(6) Fighting cancer with red wine? Molecular mechanisms of resveratrol by Kraft TE1, Parisotto D, Schempp C, Efferth T.(PubMed)
(7) Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines by Wang Y1, Romigh T, He X, Orloff MS, Silverman RH, Heston WD, Eng C.(PubMed)
(8) Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells by Zhu Y1, He W1, Gao X1, Li B1, Mei C1, Xu R1, Chen H1.(PubMed)
(9) (Z)3,4,5,4'-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small celllung cancer via selectively elevating intracellular calcium level by Fan XX1, Yao XJ1, Xu SW1, Wong VK1, He JX2, Ding J3, Xue WW4, Mujtaba T5, Michelangeli F5, Huang M3, Huang J2, Xiao DK2, Jiang ZB1, Zhou YL1, Kin-Ting Kam R6, Liu L1, Lai-Han Leung E1.(PubMed)
(10) CArG-driven GADD45α activated by resveratrol inhibits lung cancer cells by Shi Q1, Geldenhuys W2, Sutariya V3, Bishayee A4, Patel I5, Bhatia D5.(PubMed)
(11) [Effects of wine polyphenols on cancer prevention].[Article in Spanish] by Sancho M1, Mach N2.(PubMed)

Thursday, December 24, 2015

Research attributed to Kyle J. Norton, The Smoothie Recipe of Blue berry Juice, dart chocolate and Green tea for prevention and treatment of Stress

Kyle J. Norton(Scholar, Master of Nutrients). All right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for people with high risk Stress and Stress
Yield: 2 serving (about 8 ounce each)
1 cup organic mulberry fruit juice (Blueberry Juice)
1.5 grams of dart chocolate
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)


1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Stress is the reaction of human being when there is a feeling of strain and pressure. Mild forms of stress are considered healthy but overwhelming by stress may induce some psychological ailments.
According to Dr, Kala M1, Nivsarkar M. stress can trigger for reproductive dysfunctions,in duce anhedonia, depression and anxiety as well as increased the production of reactive oxygen species(ROS)(1).



Organic mulberry fruits, containing high amount of anthocyanins has been found to process anti cancer(2) and inflammatory diseases(3) through vary mechanisms.
According to the Meikai University School of Dentistry, mulberry juice may also consist of anti stress activity 4 hours after cessation of oral administration due to its antioxidant effects(4).
In animal study, the juice also exhibited anti stress property throughi its radical scavenging activity(5), DR. Sakagami H and the research team at the Meikai University School of Dentistry suggested


Dark chocolate or plain chocolate produced by seeds of cocoa directly has found to blocks feelings of pain and depression temporarily due to the effects of its phytochemical polyphenols(6).In the comparison of Dark chocolate (DC), Milk chocolate (MC), Whitechocolate (WC). in 60 subjects, Intake of dark chocolate daily during a period of 2 weeks effectively reduce stress in females(6).
In psychological stress in healthy men with aged 20-50 years, Dr. von Känel R and the research team at the University of Konstanz, said,"(Through) attenuated stress reactivity of the hypercoagulability marker D-dimer,... a single consumption of flavonoid-rich dark chocolate blunted the acute prothrombotic response to psychosocial stress"(7).

Furthermore, 3 weeks consumption of 50 g flavonoid-rich dark chocolate also showed to reduce oxidative stress through improving the lipoprotein profile in healthy humans, more so in women than in men, and inducing a protective effect on the cardiovascular system(8).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.
according to the literatures found on PubMed, green phtochemicals showed effectively in reduce symptoms induced by psychological stress.
According to the University of Shizuoka, intake of green tea inhibited the increase of stress effect through improving the mood swing during and after mental stress load(9), attenuating learning and memory impairment(10).
Dr. Ross SM said,"Green tea also reduce psychological stress through its antioxidant L-theanine (suntheanin): an amino acid derived from green tea"(11).

People who are at increased risk of stress due to family history or gene mutation .....should drink at least one cup daily and people with chronic stress should drink the smoothie as much as they can, depending to digestive toleration.
Change of life style and diet pattern are also recommended.



All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Role of cortisol and superoxide dismutase in psychological stress induced anovulation by Kala M1, Nivsarkar M2.(PubMed)
(2) Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer by Peiffer DS1, Wang LS2, Zimmerman NP3, Carmella SG4, Kuo CT5, Chen JH2, Oshima K6, Huang YW7, Hecht SS8, Stoner G9.(PubMed)
(3) The anti-inflammatory and antifibrosis effects of anthocyanin extracted from black soybean on a Peyroniedisease rat model by Sohn DW1, Bae WJ2, Kim HS1, Kim SW1, Kim SW3.(PubMed)
(4) Anti-stress, anti-HIV and vitamin C-synergized radical scavenging activity of mulberry juice fractions by Sakagami H1, Asano K, Satoh K, Takahashi K, Kobayashi M, Koga N, Takahashi H, Tachikawa R, Tashiro T, Hasegawa A, Kurihara K, Ikarashi T, Kanamoto T,Terakubo S, Nakashima H, Watanabe S, Nakamura W.(PubMed)
(5)
(6) Effects of chocolate intake on Perceived Stress; a Controlled Clinical Study by Al Sunni A1, Latif R1.(PubMed)
(7) Effects of dark chocolate consumption on the prothrombotic response to acute psychosocial stress in healthy men by von Känel R, Meister RE, Stutz M, Kummer P, Arpagaus A, Huber S, Ehlert U, Wirtz PH1.(PubMed)
(8) Effect of consumption of dark chocolate on oxidative stress in lipoproteins and platelets in women and in men by Nanetti L1, Raffaelli F, Tranquilli AL, Fiorini R, Mazzanti L, Vignini A.(PubMed)
(9) Intake of green tea inhibited increase of salivary chromogranin A after mental task stress loads by Yoto A1, Murao S, Nakamura Y, Yokogoshi H(PubMed)
(10) Epigallocatechin-3-gallate attenuates impairment of learning and memory in chronic unpredictable mild stress-treated rats by restoring hippocampal autophagic flux by Gu HF1, Nie YX2, Tong QZ3, Tang YL4, Zeng Y2, Jing KQ2, Zheng XL5, Liao DF6.(PubMed)
(11) L-theanine (suntheanin): effects of L-theanine, an amino acid derived from Camellia sinensis (green tea), onstress response parameters by Ross SM1.(PubMed)

Wednesday, December 23, 2015

Research attributed to Kyle J. Norton, The Smoothie Recipe of Tangerine peels and Grapes For Lung Cancer


Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with lung cancer and high risk of the disease

Yield: 2 serving (about 8 ounce each)
1 1/2 cups grapes of any kind with seeds
1 medium tangerine peels
1 cup rice milk


1. Place the grapes, tangerine peels, rice milk, in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

Recent studies suggested that tangerine peels and grape skin and seeds may have a potential effect on treatment of patient with lung cancer.

Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistic.

Tangerine, one of the winter fruits found on Chinese New year represent prosperity and good fortune, now has been cultivated all over the world in suitable climate for commercial and health benefits. The peel of the fruit also has been recorded in Chinese herbal medicine over thousand of years for treatment of respiratory diseases, including cough, asthma,.........

Epidemiological study suggested that Tangeretin has long been found to consist the ability in inhibition of apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways (such as P53 antigen and caspase activation).

Tangeretin, a major phytochemicals in tangerine peels, in vitro and in vivo exhibited anti lung cancer effects through induced CL1-5 cell apoptosis and autophagy and inhibited NSCLC cell proliferation, and induce G(2)/M phase arrest and via the mitochondrial apoptotic pathway and autophagy(1)

"By interference of the cancer cell division and destruction of the function of new cell formation in mitochondrial apoptotic pathway involved the The Bcl-2 family of proteins" Kyle J. Norton said " The finding of tangeretin may provide us a natural sources for treatment of lung with little or no adverse effect".

In support of the finding, Dr. Charoensinphon N and the research team at the University of Massachusetts suggested, in comparison of the effects of Tangeretin (TAN) and 5-demethyltangeretin (5DT) on three human nonsmall cell lung cancer (NSCLC) cells, 5DT inhibited NSCLC cell growth by inducing G2/M cell cycle arrest and apoptosismuch stronger than the phytochemical TAN(2).
Other study also insisted that the effectiveness of the phytochemicals for treatment of lung cancer in tangerine peel may be associated to the suppression of inflammation and cell proliferation in the Nuclear factor-κB (NF-κB) family and certain signaling proteins(5).

Grape skin and seeds contains many concentrations, including vitamin E, flavonoids, linoleic acid,oligomeric proanthocyanidins(OPCs), etc..The herb has been used in traditional medicine as antioxidant, anti-inflammatory agents.

Resveratrol, an phytochemical found abundantly in grape seed and skin is a class of Stilbenoids. Epidemiologically, the antioxidant has found effectively for treatment many types of cancer(6) including prostate cancer(7).
Dr. Zhu Y and the research team at the Genomic Medicine Institute, Cleveland Clinic indicated the effects of resveratrol for treatment of non-small cell lung cancer (NSCLC) patients with activating EGFR mutations, probably through induction of cell apoptosis, autophagy, cell cycle arrest and senescence accompanied by increased expression of anti inflammation and proliferation pathways(8).

Analogue of resveratrol, (Z)3,4,5,4'-trans-tetramethoxystilbene (TMS), also inhibited gefitinb-resistant non-small cell lung cancer through inducing apoptosis and autophagy via mediation of calcium signaling pathway(9).

Other studies in supports of the above include the joint study lead by the Northeast Ohio Medical University, Rootstown,showed that resveratrol inhibits lung cancer cells, through activation of GADD45α in induction of cancer cell suicide(10). Dr. Sancho M and Dr. Mach N said," The wine polyphenols plays a significant role as antioxidant and prooxidant in cancer, although more extensive studies are required to determine the clinical significance in humans"(11).

" The combination of tangerine and grape smoothie may hold a key to reduce risk for people who are at higher risk of lung cancer as well as for treatment of patient who have already developed the disease" Mr. Kyle J. Norton said, " people with lung cancer in any stage should drink as much as they can, depending to the digestive toleration"


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months




References

(1) Tangeretin Derivative, 5-Acetyloxy-6,7,8,4'-tetramethoxyflavone Induces G2/M arrest, Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer Cells In vitro and In vivo(PubMed)Li YR1, Li S2, Ho CT3, Chang YH1, Tan KT1,4, Chung TW5, Wang BY6, Chen YK7, Lin CC1.

(2) 5-demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis by Charoensinphon N1, Qiu P, Dong P, Zheng J, Ngauv P, Cao Y, Li S, Ho CT, Xiao H.(PubMed)
(3) Tangeretin, a citrus polymethoxyflavonoid, induces apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways by Dong Y1, Cao A2, Shi J3, Yin P2, Wang L2, Ji G4, Xie J4, Wu D2.(PubMed)
(4) Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells by Zhang X1, Zheng L1, Sun Y1, Wang T2, Wang B3(PubMed)
(5) Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells by Chen KH1, Weng MS, Lin JK.(PubMed)
(6) Fighting cancer with red wine? Molecular mechanisms of resveratrol by Kraft TE1, Parisotto D, Schempp C, Efferth T.(PubMed)
(7) Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines by Wang Y1, Romigh T, He X, Orloff MS, Silverman RH, Heston WD, Eng C.(PubMed)
(8) Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells by Zhu Y1, He W1, Gao X1, Li B1, Mei C1, Xu R1, Chen H1.(PubMed)
(9) (Z)3,4,5,4'-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small celllung cancer via selectively elevating intracellular calcium level by Fan XX1, Yao XJ1, Xu SW1, Wong VK1, He JX2, Ding J3, Xue WW4, Mujtaba T5, Michelangeli F5, Huang M3, Huang J2, Xiao DK2, Jiang ZB1, Zhou YL1, Kin-Ting Kam R6, Liu L1, Lai-Han Leung E1.(PubMed)
(10) CArG-driven GADD45α activated by resveratrol inhibits lung cancer cells by Shi Q1, Geldenhuys W2, Sutariya V3, Bishayee A4, Patel I5, Bhatia D5.(PubMed)
(11) [Effects of wine polyphenols on cancer prevention].[Article in Spanish] by Sancho M1, Mach N2.(PubMed)

Tuesday, December 22, 2015

The Incredible and Curable Smoothie of Cooked Tomatoes and Green Tea for Prostate cancer


Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with High blood Cholesterol and high risk of the syndrome

Yield: 2 serving (about 8 ounce each)
1 1/2 cups COOKED tomatoes
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)


1. Place the COOKed tomatoes, green tea, in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately


The dream of finding the natural ingredient for prevention and treatment of prostate cancer with adverse effects in replacement of chemotherapy has not been abated. Some ingredients have to discard due to it can achieve the same potent results in human trials.

The widespread of prostate cancer, once considered a disease of aging male, now have become major concerns of governments and scientific community in South East Asian with tendency to effect even younger age population.

Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth with possibility of spreading to the distant parts of the body. Most prostate cancers are slow growing. Enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

Recent study suggested that combination of tomato and green tea may have a potent and pharmaceutical values for treatment of prostate cancer, probably due to tomatoes' and green tea's phytochemicals lycopene(1) and catchins(2)

Tomato is a red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house.

Intake large amount of cooked tomatoes has shown effectively in reduced risk(4) and for treatment of patient with prostate cancer(1). The Royal Victoria Hospital and McGill University, in the review of 11 case-control studies and 10 cohort studies or nested case-control studies presented data on the use of tomato, tomato products, or lycopene and met our inclusion criteria, said, "tomato products may play a role in the prevention of prostate cancer. However, this effect is modest and restricted to high amounts of tomato intake"(3).

Furthermore, in a Systematic Review and Meta-Analysis, the finding of the lycopene as an antioxidant agent with potential anticancer and anti prostate cancer progression properties only with the concentration of circulating lycopene between 2.17 and 85 μg/dL(5).

In fact, epidemiological studies also suggested that lycopene effectively in regulating cell growth, on a prostate cancer cell line expressing the androgen receptor(6), stopping cell proliferation of human prostate cancer cell line PC-3(7) and inhibiting adhesion and migration properties of the cells(8).
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

Green tea catechins, one of the major phytochemical constituent showed effectively in treating premalignant lesions before development of prostate cancer (CaP) and reducing symptoms of benign prostate hyperplasia, according to the University of Parma(2).
Dr. Bettuzzi S and the research team at the University of Parma, insisted, Green Tea Catechins (GTCs) can be used as first line prevention therapy for treatment of high risk of Prostate cancer (CaP) in in combination with the 8-genes signature profiling in tissue needle biopsies(9).In deed, in prostate cancer cell lines, such as PNT1a, LNCaP and PC3, green tea catechins, induced cell deaths(10), cancer cell apoptosis(11) as well as exhibited protection against oxidative DNA damage and stress in human prostate cause of prostate cancer(12).

Men who are at increased of prostate cancer due to family history or gene mutation .....should drink at least one cup daily and men with prostate cancer should drink the smoothie as much as they can, depending to digestive toleration.
Change life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Lycopene/tomato consumption and the risk of prostate cancer: a systematic review and meta-analysis of prospective studies by Chen J1, Song Y, Zhang L.(PubMed)
(2) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study by Bettuzzi S1, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A.(PubMed)
(3) The role of tomato products and lycopene in the prevention of prostate cancer: a meta-analysis of observational studies by Etminan M1, Takkouche B, Caamaño-Isorna F.(PubMed)
(4) Tomato products, lycopene, and prostate cancer risk by Miller EC1, Giovannucci E, Erdman JW Jr, Bahnson R, Schwartz SJ, Clinton SK.(PubMed)
(5) Lycopene and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis by Chen P1, Zhang W, Wang X, Zhao K, Negi DS, Zhuo L, Qi M, Wang X, Zhang X.(PubMed)
(6) Serum from rats fed red or yellow tomatoes induces Connexin43 expression independently from lycopene in aprostate cancer cell line by Gitenay D1, Lyan B, Talvas J, Mazur A, Georgé S, Caris-Veyrat C, Rock E.(PubMed)
(7) [Effect of lycopene on proliferation and cell cycle of hormone refractory prostate cancer PC-3 cell line].[Article in Chinese] by Wang A1, Zhang L.(PubMed)
(8) Lycopene treatment of prostate cancer cell lines inhibits adhesion and migration properties of the cells by Elgass S1, Cooper A1, Chopra M1.(PubMed)
(9) Clinical relevance of the inhibitory effect of green tea catechins (GtCs) on prostate cancer progression in combination with molecular profiling of catechin-resistant tumors: an integrated view.
Bettuzzi S1, Rizzi F, Belloni L.(PubMed)
(10) Polyphenon E(R), a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis by Rizzi F1, Naponelli V, Silva A, Modernelli A, Ramazzina I, Bonacini M, Tardito S, Gatti R, Uggeri J, Bettuzzi S.(PubMed)
(11) Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells by Hagen RM1, Chedea VS, Mintoff CP, Bowler E, Morse HR, Ladomery MR.(PubMed)
(12) Protection against oxidative DNA damage and stress in human prostate by glutathione S-transferase P1 by Kanwal R1, Pandey M, Bhaskaran N, Maclennan GT, Fu P, Ponsky LE, Gupta S.(PubMed)

Monday, December 21, 2015

The Marvelous Smoothie of Green tea and Blue berry for Prevention and Treatment of Depression



Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with Depression and high risk of the syndrome

Yield: 2 serving (about 8 ounce each)
1 1/2 cups blue berries
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place the blue berries and green tea in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately


The combination of green tea and berries recently have drawn attention of the science community as their phytochemicals catechins and Anthocyanins have shown effectively in attenuate depressive symptoms in animal model study(1).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

The drink has showed to exhibit antidepressive-like effects through its anti-oxidant phenolic compounds, epidemiological studies suggested(2).

In the study of total of 2006 Japanese employees aged 19-69 years, dietary intake played an impotant role for the development of depressive symptoms. Employees who drink green tea and fruits daily are associated with fewer depressive symptoms(3).

According to the cupuncture and Meridian Science Research Center, long term catechins oral administration reduce the expression of dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis of that improved symptoms like depression and anxiety(5).

Dr. Trebatická J and Dr. Ďuračková Z in the study of the prevalence of psychiatric disorders permanently increases said, "Polyphenols in the diet have the potential to become medicaments in the field of mental health after a thorough study of their mechanism of action" of that include green tea phytochemicals(4).

Blueberry is a flower plant, belong to the family Eriaceae and native to Northern America. The berries now is become commercial cultivation crops in northern Russia, China, and Japan because of its health benefits induced by anthocyanins, proanthocyanidins and other flavonoids(6).

Methanol extract containing anthocyanins (MHR) (30 and 100 mg/kg) and anthocyanidins (AHR), according to the study by the MGV's Pharmacy College, exhibited potential antidepressant activity through dopaminergic, noradrenergic and serotonergic effects(7).

Berry anthocyanins reduced elevation of the expression monoamine oxidases (MAO) A and B in causation of depression, anxiety, and neurodegenerative disease, the University of Regensburg suggested(8)

This finding of the effectiveness of Green Tea catechins and blueberry Anthocyaninsa may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for treatment of depression with little or no adverse effects.

People who are at high risk of depression due to chronic diseases should drink at least one cup daily and people with depression should drink the smoothie as much as they can, depending to digestive toleration.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Natural products, micronutrients, and nutraceuticals for the treatment of depression: A short review by Nabavi SM, Daglia M, Braidy N, Nabavi SF.(PubMed)
(2) Antidepressive-like effects and antioxidant activity of green tea and GABA green tea in a mouse model of post-stroke depression by Lorenzo AD1, Nabavi SF2, Sureda A3, Moghaddam AH4, Khanjani S4, Arcidiaco P5, Nabavi SM2, Daglia M1.(PubMed)
(3) Dietary patterns derived by reduced rank regression (RRR) and depressive symptoms in Japanese employees: The Furukawa nutrition and health study by Miki T1, Kochi T2, Kuwahara K3, Eguchi M2, Kurotani K4, Tsuruoka H2, Ito R2, Kabe I2, Kawakami N5, Mizoue T4, Nanri A4.(PubMed)
(4) Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy? by Trebatická J1, Ďuračková Z2.(PubMed)
(5) Chronic administration of catechin decreases depression and anxiety-like behaviors in a rat model using chronic corticosterone injections by Lee B1, Sur B, Kwon S, Yeom M, Shim I, Lee H, Hahm DH.(PubMed)
(6) Berry fruits as a source of biologically active compounds: the case of Lonicera caerulea by Svarcova I1, Heinrich J, Valentova K.(PubMed)
(7) Antidepressant-like activity of anthocyanidins from Hibiscus rosa-sinensis flowers in tail suspension test and forced swim test by Shewale PB1, Patil RA, Hiray YA.(PubMed)
(8) Berry anthocyanins and their aglycons inhibit monoamine oxidases A and B. by Dreiseitel A1, Korte G, Schreier P, Oehme A, Locher S, Domani M, Hajak G, Sand PG.(PubMed)

Sunday, December 20, 2015

The best of Smoothie of Green (unripe) Banana, Pineapple and Green tea for Insulin Resistance

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with Insulin Resistance and high risk of the syndrome


Yield: 2 serving (about 8 ounce each)
1 cup green banana
1/2 cup pineapple
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)


1. Place the green bananas, pineapples and green tea, and in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The dream of finding the natural ingredient for prevention and treatment of Insulin Resistance on prediabetes without adverse effects in replacement of conventional medication has not been abated. Some ingredients have to discard due to it can achieve the same potent results in human trials.

Insulin resistance (IR) is a medical condition of the body cells fail to respond to the normal actions of the hormone insulin against intake of glucose.

The recent studies insisted that intake of green banana(1), pineapple(5) and green tea are(7) associated to prevention and treatment of Insulin Resistance in patient with prediabetes.
Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belongs to the family of the lily and the orchid.


According to the study by the Universidad Juárez Autónoma de Tabasco (UJAT), administration of native banana starch (NBS) reduced body weight and improve insulin resistance in in obese with type 2 diabetics(2).
Dr. Miura T and the research ream at the Suzuka University of Medical Science, insisted that Banaba (Lagerstroemia speciosa L.) extracts decreased blood sugar levels within 30 of orla administration in human subjects. Its corosolic acid also exhibits antihyperlipidemic and antioxidant activities in reduced insulin sensitivity through decreased the levels of high sensitivity C-reactive protein, a marker of inflammation, after 6 weeks(3).

In KK-Ay diabetic mice study, banana's corosolic acid oral administration reduced the blood glucose levels in 2 weeks, lowered plasma insulin levels and blood glucose significantly in an insulin tolerance test(4).

Pineapple is a species of Ananas Comos. belong to the family Bromeliaceae and native to southern Brazil and Paraguay. Today it is widely cultivated for commercial and its rich of vitamins and mineral and digesting enzyme bromelin which seems to help digestion at the end of a high protein meal. It is second only to banana as America's most favourite tropical fruit.

Ethanolic extracts of Ananas comosus L. leaves (AC) is found effectively in reduced insulin resistance in HepG2 cells, in high-fat diet-fed and low-dose streptozotozin-treated diabetic rats, according to the study by the Tsinghua University(5).

In diabetic-dyslipidemic rats, oral intake of the extract also significantly inhibited the increase in blood glucose in oral glucose tolerance test, through its anti-diabetic, anti-hyperlipidemic and anti-oxidative activities(6).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years used in traditional Chinese medicien for treatment of variety of diseases, including cancers and heart diseases.

In a double-blind, placebo-controlled trial, 56 obese subjects, daily supplementation with 379 mg of green tea extract (GTE) not only influences blood pressure, inflammation and oxidative stress, and lipid profile, but alos insulin resistance, in patients with obesity-related hypertension(7).

Dr. Hsu CH and the research team at the National Yang-Ming University, also support the use of decaffeinated green tea extract (GTE) for reduction of insulin resistance, according to the clinical result of conducted from December 2007(8).

Selenium-containing tea polysaccharides (Se-GTP), significantly improved insulin sensitivity, and reduced liver steatosis and oxidative stress damage at doses of at 400 and 800 mg in a high fructose-induced insulin resistance and hepatic oxidative injury mice study(9).

Taking all together, Smoothie of green bananas, pineapples and green tea may be a potent drink for reduced risk and treatment of Insulin Resistance.
People who are at increased of Insulin Resistance due to family history, gene mutation, obesity, .....should drink at least one serving daily and people with chronic Insulin Resistance should drink the smoothie as much as they can depending to digestive toleration.
Change life style and diet pattern are also recommended.



All Forms of Arthritis are Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Women with metabolic syndrome improve antrophometric and biochemical parameters with green banana flour consumption by Tavares da Silva S1, Araújo Dos Santos C2, Marvila Girondoli Y3, Mello de Azeredo L4, Fernando de Sousa Moraes L5, Keila Viana Gomes Schitini J6, Flávio C de Lima M7, Cristina Lopes Assis Coelho R8, Bressan J9.(PubMed)
(2) Effects of native banana starch supplementation on body weight and insulin sensitivity in obese type 2 diabetics by Ble-Castillo JL1, Aparicio-Trápala MA, Francisco-Luria MU, Córdova-Uscanga R, Rodríguez-Hernández A, Méndez JD, Díaz-Zagoya JC.(PubMed)
(3) Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome by Yamaguchi Y1, Yamada K, Yoshikawa N, Nakamura K, Haginaka J, Kunitomo M.(PubMed)
(4) Antidiabetic effects of corosolic acid in KK-Ay diabetic mice by Miura T1, Ueda N, Yamada K, Fukushima M, Ishida T, Kaneko T, Matsuyama F, Seino Y.(PubMed)
(5) Effect of ethanolic extracts of Ananas comosus L. leaves on insulin sensitivity in rats and HepG2 by Xie W1, Wang W, Su H, Xing D, Pan Y, Du L.(PubMed)
(6) The effects of Ananas comosus L. leaves on diabetic-dyslipidemic rats induced by alloxan and a high-fat/high-cholesterol diet by Xie W1, Xing D, Sun H, Wang W, Ding Y, Du L.(PubMed)
(7) Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients by Bogdanski P1, Suliburska J, Szulinska M, Stepien M, Pupek-Musialik D, Jablecka A.(PubMed)
(8) Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebo-controlled clinical trial by Hsu CH1, Liao YL, Lin SC, Tsai TH, Huang CJ, Chou P.(PubMed)
(9) Selenium-containing polysaccharides from Ziyang green tea ameliorate high-fructose diet induced insulin resistance and hepatic oxidative stress in mice by Ren D1, Hu Y, Luo Y, Yang X.(PubMed)

Saturday, December 19, 2015

The Unbelievable and incredible smoothie Tangerine, Carrot and Green tea for reduced risk and treatment of Bladder Cancer


Kyle J. Norton(Scholar and Master of Nutrients) all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for people with high risk Bladder Cancer and Bladder Cancer
Yield: 2 serving (about 8 ounce each)
1 cup tangerines
1/2 cup carrot
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)


1. Place the tangerines, carrot and green tea, in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Bladder cancer is most common type of cancer that effect men twice as frequently as it effects women. Usually it starts from the lining the bladder caused by several types of malignant growths of the urinary bladder cells.

The finding the natural ingredient for prevention and treatment of bladder cancer to replace the toxicity of chemotherapy has been facing many obstacles. Many initially potentially therapeutic values working in animal studies does not produce the same effectiveness in human trials.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

Epidemiological evidences, suggested that chronic drinking of green tea is associated to reduce risk of bladder cancer, depending to total fluid intake(1).
According to the Maastricht University, in the study of multivariable case-cohort analysis based on 569 bladder cancer cases, suggested that tea consumption was inversely associated with bladder cancer, regarded to the daily quantities(2).
Dr. Wang X and the research team at the Zhejiang University, in the study of bladder cancer twith analysis of types of tea, gender,ethnicity and smoking status showed that in Asian people, drinking green tea may have a protective effect on bladder cancer(3).

Tangerines, an orange-colored citrus fruit, a type of, mandarin orange originated to Tangier, Morocco, are now cultivated all over the world in suitable climate for commercial profits due to their health effects.

According to a Serbian study, tangerines are found to associated to decrease risk of bladder cancer(4).
In the study of total of 30 newly diagnosed bladder cancer patients and the same number of controls matched by sex, age suggested that daily intake of tangerines exhibited the inverse association of bladder cancer risk(5).
In fact, according to Dr.Brinkman M. and Dr. Zeegers MP.said,"intake of Citrus fruits, (including tangerines induced) a possible protective effect against bladder cancer"(6).

Carrot can grow to 3ft tall. It is root vegetable with orange color normally, a sub spices of Daucus carota, belongs to the family Apiaceae, native to Asian and Europe.

Consumption of carrot is found to reduced risk of bladder cancer(6). Risk of bladder increased with lower serum of vitamin A(7)(8) as well as infrequent intake of carrot daily, in the study of a total of 569 bladder cancer patients and 1025 age-matched controls admitted to Roswell Park Memorial Institute(7).
Dr, Tang JE and the research team at the Huzhou Teachers College, said," high vitamin A intake was associated with a lower risk of bladder cancer. Larger studies with prospective design and rigorous methodology should be considered to validate the current findings" in the review of 25 articles on dietary vitamin A or blood vitamin A were included according to the eligibility criteria(9).
Its retinoids, a class of vitamin A can act as bladder cancer treatment or prevention through its essential role in epithelial and general cell maturation and function as well as immune activation(10).

People who are at increased risk of Bladder Cancer due to family history, gene mutation,....should drink at least one cup daily and people with Bladder Cancer should drink the smoothie as much as they can, depending to digestive and liver toleration.


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


References

(1) The association of tea consumption with bladder cancer risk: a meta-analysis by Wu S1, Li F, Huang X, Hua Q, Huang T, Liu Z, Liu Z, Zhang Z, Liao C, Chen Y, Shi Y, Zeng R, Feng M, Zhong X, Long Z, Tan W, Zhang X.(PubMed)
(2) Are coffee, tea, and total fluid consumption associated with bladder cancer risk? Results from the Netherlands Cohort Study by Zeegers MP1, Dorant E, Goldbohm RA, van den Brandt PA.(PubMed)
(3) A meta-analysis of tea consumption and the risk of bladder cancer by Wang X1, Lin YW, Wang S, Wu J, Mao QQ, Zheng XY, Xie LP.(PubMed)
(4) [Risk factors for urinary bladder cancer].[Article in Serbian by Radosavljevic V1, Jankovic S, Markovic-Denic Lj.(PubMed)
(5) Diet and bladder cancer: a case-control study by Radosavljević V1, Janković S, Marinković J, Dokić M.(PubMed)
(6) Nutrition, total fluid and bladder cancer by Brinkman M1, Zeegers MP.(PubMed)
(7) Dietary risk factors in human bladder cancer by Mettlin C, Graham S.(PubMed)
(8) Relative importance of risk factors in bladder carcinogenesis: some new results about Mediterranean habits by Momas I1, Daurès JP, Festy B, Bontoux J, Grémy F.(PubMed)
(9) Vitamin A and risk of bladder cancer: a meta-analysis of epidemiological studies by Tang JE, Wang RJ1, Zhong H, Yu B, Chen Y.(PubMed)
(10) Retinoids and their biological effects against cancer by Alizadeh F1, Bolhassani A2, Khavari A1, Bathaie SZ3, Naji T4, Bidgoli SA4.(PubMed)

Friday, December 18, 2015

The Smoothie of Cinnamon, Whole Food Papaya and Green Tea for reduced Risk and Treatment of Diabetes

Kyle J. Norton(Scholar), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with higher risk of diabetes and Diabetes

Yield: 2 serving (about 8 ounce each)
1 3/4 cup whole food papaya
1/4 tsp cinnamon

1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)
1. Place whole food papaya, cinnamon and green tea drink in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of diabetes has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases,diabetes is also caused by allergic reactions of cells in the immune system

Cinnamon, a kitchen spicy in many cultures, may have gained many believers, including medical professions because of its anti diabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects. According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce the blood sugar significantly with little or no adverse effects.

The herb has been use in herbal and traditional medicine as anti-fungal and bacteria level to improve reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(1).

According to the 2011 statistic from National Diabetes InformationClearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, had diabetes in 2010, about 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010 and approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.

In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, showed a significant reduction of blood triglyceride levels in the low-dose group, after 3 months of oral administration(2)

Some researchers suggested that cinnamon extract may improve fasting blood glucose levels and glucose tolerance without altering the insulin secretion, through lower triglyceride and increased liver glycogen content and improved insulin action in liver tissues(3).

Dr. Kim SH and Dr. Choung SY. told PubMed "The effect of cinnamon in significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR(in regulation of metabolism (carbohydrate, lipid, protein))-medicated glucose and lipid metabolism"(4)

In support of the above, chromium(Cr) and polyphenols found in cinnamon(Cinnamomon cassia) indicated a improvement of glucose, insulin, cholesterol and HbA1c(Glucose lab test) in patients with type 2 diabetesfollowing Cr supplementation, in a double-blind placebo-controlled study(7).

Unfortunately, according to the Western University of Health Sciences, consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose, but insisted that high degree of heterogeneity may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5)

A randomized clinical trial in which 70 Patients with type II diabetesassigned randomly two groups (35 in cinnamon and 35 in placebo group for the testing of the effect of cinnamon on the glucose level in blood, indicated an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(6).

People with Type II Diabetes may also be thinking to add whole food papaya into their diet. the recent study suggested(7) ,
The finding not only showed the effectiveness of unripe pawpaw fruit (Carica papaya) in inhibition α-amylase, α-glucosidase, but also induced lipid peroxidation in a dose-dependent manner, in rat pancreas(7).
The key enzymes of α-amylase, α-glucosidase, involved in the digestion of carbohydrates, have been linked to onset of type 2 diabetes. Inhibition of these enzymes can significantly reduce the post-prandial increase of blood glucose and have been considered by therapists in use for management of blood glucose level in type 2 diabetic and borderline patients(8).

In streptozotocin-induced diabetic rats study, the aqueous extract of leaves of C. papaya administered strongly controlled blood glucose levels(9), through prevention of hepatocyte disruption, as well as accumulation of glycogen and lipids via its hypoglycemic and antioxidant effect(10)

In a new study, conducted by the researchers at the Davis Heart and Lung Research Institute, fermented papaya preparation was tested whether it improves dermal wound healing outcomes in adult diabetic mice by preventing the risk of infections(11).
The result was astonishing, the fermentation not only up regulated the Sp1 DNA binding activity(modulating the cellular response to DNA damage) in Peripheral blood mononuclear cells (PBMC) but also the protein and mRNA expression of Rac2(regulates a number of cellular functions)(11).

A randomized controlled clinical trial conducted at the Cardiac Centre, ANDI Centre of Excellence for Biomedical and Biomaterials Research and Department of Biosciences University of Mauritius, suggested that oral administration of 6g FPP®/day for a period of 14 weeks could improve the general health status of several organs targeted by oxidative stress duringdiabetes and suggested that the supplement may be used in the management the complications of diabetes such as cardiovascular disease, neurological disease and other conditions worsened by overt inflammation and oxidative stress(12).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

Green tea has ling been known for its effect on treatment of diabetes in ancient Chinese literature, probably due to green tea phytochemical polyphenols(14).

Dr. Solayman M and the research tea at the Universiti Sains Malaysia said, "Natural products containing high polyphenol levels can control carbohydrate metabolism by various mechanisms, such as protecting and restoring beta-cell integrity, enhancing insulin releasing activity, and increasing cellular glucose uptake"(15).

In a total of 17,413 persons (6727 men and 10,686 women; 49% of the original study population) who were 40 to 65 years of age, daily drinking of green tea reduced risk of diabetes by 33%, especially in women and in overweight men(13).

Furthermore, intake of green tea of 150 ml green tea, three times a day for four weeks, has positive effect on insulin resistance and certain lipoproteins in type 2 DM, according to the Shahid Sadoughi University of Medical Science(16).

People who are at increased of diabetes due to family history, gene mutation, obesity.....should drink at least one serving daily and people with diabetes should drink no more than 4 serving a day, depending to digestive toleration.
Change life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)(7) Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya) by Oboh G, Olabiyi AA, Akinyemi AJ, Ademiluyi AO.(PubMed)
(8) Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update by Tundis R1, Loizzo MR, Menichini F.(PubMed)
(9) Antihyperglycemic and hypolipidemic activities of aqueous extract ofCarica papaya Linn. leaves in alloxan-induced diabetic rats by Maniyar Y, Bhixavatimath P.(PubMed)
(10) Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats by Juárez-Rojop IE1, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T, Bermúdez-Ocaña DY.(PubMed)
(11) Correction of aberrant NADPH oxidase activity in blood-derived mononuclear cells from type II diabetes mellitus patients by a naturally fermented papaya preparation by Dickerson R1, Deshpande B, Gnyawali U, Lynch D, Gordillo GM, Schuster D, Osei K, Roy S.(PubMed)
(12) Effects of a short term supplementation of a fermented papaya preparation on biomarkers of diabetes mellitus in a randomized Mauritian population by Somanah J1, Aruoma OI, Gunness TK, Kowelssur S, Dambala V, Murad F, Googoolye K, Daus D, Indelicato J, Bourdon E, Bahorun T.(PubMed)
(13) The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults by Iso H1, Date C, Wakai K, Fukui M, Tamakoshi A; JACC Study Group(PubMed)
(14) Polyphenols: Potential Future Arsenals in the Treatment of Diabetes by Solayman M, Ali Y, Alam F, Islam MA, Alam N, Khalil MI, Gan SH1(PubMed)
(15) Polyphenols: Potential Future Arsenals in the Treatment of Diabetes by Solayman M, Ali Y, Alam F, Islam MA, Alam N, Khalil MI, Gan SH1.(PubMed)
(16) The Effect of Green Tea versus Sour Tea on Insulin Resistance, Lipids Profiles and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial by Mozaffari-Khosravi H1, Ahadi Z1, Fallah Tafti M2.(PubMed)